Maternal gestational diabetes and infant feeding, nutrition and growth: a systematic review and meta-analysis.

Maternal gestational diabetes and infant feeding, nutrition and growth: a systematic review and meta-analysis. Br J Nutr. 2020 Jan 22;:1-37 Authors: Manerkar K, Harding J, Conlon C, McKinlay C Abstract Gestational diabetes mellitus (GDM) is a major health problem, with increased risks of obesity and diabetes in offspring. However, little is known of the effect of GDM on infant feeding, nutrition and growth, and whether these factors play a role in mediating these risks. We systematically reviewed evidence for the effect of GDM on infant feeding, nutrition and growth. We searched MEDLINE, Web-of-Science, EMBASE, CINAHL and CENTRAL for studies that reported outcomes in infants <2 years who were and were not exposed to GDM. Studies of pre-gestational diabetes were excluded. Meta-analysis was performed for three epochs (1-6, 7-12, 13-24 months), using inverse-variance, fixed-effects methods. Primary outcomes were energy intake (kJ) and body-mass-index (BMI, kg/m2). 25 studies and 308,455 infants were included. Infants exposed to GDM, compared to those not exposed, had similar BMI at age 1-6 months [standardised mean difference, SMD=0.01, 95%CI -0.04,0.06; p=0.69] and 7-12 months [SMD=0.04, 95%CI -0.01,0.10; p=0.09], reduced length at 1-6 and 7-12 months, increased whole-body fat at 1-6 months, higher rates of formula supplementation in hospital, shorter duration of breastfeeding and decreased rates of continued breastfeeding at 12 mon...
Source: The British Journal of Nutrition - Category: Nutrition Authors: Tags: Br J Nutr Source Type: research