Immune system cells contribute to the invading capacity of brain tumors

(Universitat Autonoma de Barcelona) An article published in Brain Communications, coordinated by Carlos Barcia, researcher at Institut de Neuroci è ncies de la UAB, describes how the immune system facilitates the expansion of tumor cells in the brain. The study was performed on human samples of glioblastoma, the most aggressive brain tumor, and on cell culture models. These findings will help to develop treatments for this type of tumor, for which there is not an effective therapy at the moment.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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Conclusion: Four immunophenotypes were found in GBM vessels, corresponding to endotheliocytes, Pcs, Tcs, and a mixed Pc/Tc immunophenotype. These and forthcoming improvements in our understanding of the origin and function of Tcs, including their relationship with Pcs, are necessary steps in oncology. Study of these cell types (Tcs, Pcs) and their roles in brain tumor oncogenesis will likely enable improved targeted therapies and support development of new forms of anti-neoplastic drugs. PMID: 32064038 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Dagmar Turner, whose performance was caught on video, said the thought of losing her ability to play was "heart-breaking.”
Source: Science - The Huffington Post - Category: Science Source Type: news
Publication date: 18 February 2020Source: Cell Reports, Volume 30, Issue 7Author(s): Rocco Lucero, Valentina Zappulli, Alessandro Sammarco, Oscar D. Murillo, Pike See Cheah, Srimeenakshi Srinivasan, Eric Tai, David T. Ting, Zhiyun Wei, Matthew E. Roth, Louise C. Laurent, Anna M. Krichevsky, Xandra O. Breakefield, Aleksandar MilosavljevicSummaryGlioblastoma (GBM) is characterized by aberrant vascularization and a complex tumor microenvironment. The failure of anti-angiogenic therapies suggests pathways of GBM neovascularization, possibly attributable to glioblastoma stem cells (GSCs) and their interplay with the tumor micro...
Source: Cell Reports - Category: Cytology Source Type: research
Brooke Warren Phuoc Le By PHUOC LE, MD and BROOKE WARREN In the 1970s, Jean Whitehorse, a member of the Navajo Nation, went to a hospital in New Mexico for acute appendicitis. Years later, she found out the procedure performed was not just an appendectomy – she had been sterilized via tubal ligation. Around the same time, a Northern Cheyenne woman was told by a doctor that a hysterectomy would cure her headaches. After the procedure, her headaches persisted. Later, she found out a brain tumor was causing her pain, not a uterine problem. Like Whitehorse and the Northern Cheyenne woman, thousands of ...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Health disparities Medical Practice Physicians Arc Health Brooke Warren eugenics legal system native american Phuoc Le sterlilizations Source Type: blogs
Bonifatius Hospital in Lingen to Be Among the First in Europe to Offer the Latest Advances in Stereotactic Radiosurgery SAN CARLOS, Calif., Feb. 19, 2020 -- (Healthcare Sales &Marketing Network) -- ZAP Surgical Systems, Inc. today announced an agreeme... Devices, Oncology, Neurosurgery ZAP Surgical Systems, ZAP-X, stereotactic, radiosurgery, radiotherapy
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news
In this study we have performed chronoamperometry on single stranded and double stranded DNA/6-mercapto-1-hexanol (MCH) mixed SAMs on gold electrodes in the presence of hexaammine ruthenium(III) (RuHex) to monitor the DNA modification with cis-diamminedichloroplatinum(II) (cisplatin). Our EQCM studies confirmed that the redox response of electrostatically bound RuHex is capable of providing quantitative information regarding the extent of DNA cross-linking with cisplatin. We believe that this method can be used in studies to test the interactions of cancer chemotherapeutic medications like cisplatin with ss &dsDNA and ...
Source: Journal of Electroanalytical Chemistry - Category: Chemistry Source Type: research
(LONDON) — Surgeons at King’s College Hospital in London removed a brain tumor from a woman who played the violin during the procedure. Doctors for violinist Dagmar Turner, 53, mapped her brain before the surgery to identify areas that were active when she played the instrument and those responsible for controlling language and movement. Doctors then woke her in mid-procedure so she could play to “ensure the surgeons did not damage any crucial areas of the brain that controlled Dagmar’s delicate hand movements,” the hospital said in a statement. “We knew how important the violin is to Da...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized health onetime United Kingdom Source Type: news
ConclusionIA drug delivery may significantly affect the way treatments are delivered to patients with brain tumors, and in particular GBM. With refinement and standardization of the techniques of IA drug delivery, improved drug selection and formulations, and the development of methods to minimize treatment-related neurological injury, IA therapy may offer significant benefits for the treatment of brain tumors.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
Glioma is the most common and aggressive primary brain tumor with high mortality rate around the world. LncRNAs have been identified to play key roles in tumorigenesis in various cancers, including glioma. How...
Source: Cancer Cell International - Category: Cancer & Oncology Authors: Tags: Primary research Source Type: research
Conclusions: Brain tumors especially germinoma are associated with the development of hypothalamic–pituitary antibodies and pituitary defects. The correct interpretation of APA/AHA antibodies is essential to avoid a misdiagnosis of an autoimmune infundibulo-neurohypophysitis or pituitary hypophysitis in patients with germinoma.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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