Twelve weeks of exenatide treatment increases [18F]fluorodeoxyglucose uptake by brown adipose tissue without affecting oxidative resting energy expenditure in nondiabetic males

Brown adipose tissue (BAT) improves energy metabolism by combusting glucose and lipids into heat. Agonism of the glucagon-like peptide-1 receptor (GLP-1R) within the central nervous system activates BAT in mice. Moreover, in patients with type 2 diabetes, GLP-1R agonism lowers body weight and improves glucose and lipid levels, possibly involving BAT activation. Interestingly, people from South Asian descent are prone to develop cardiometabolic disease. We studied the effect of GLP-1R agonism on BAT in humans, specifically in South Asians and Europids without obesity or type 2 diabetes.

Source: Metabolism - Clinical and Experimental - January 22, 2020 Category: Biomedical Science Authors: Laura G.M. Janssen, Kimberly J. Nahon, Katrien F.M. Brack é, Dennis van den Broek, Renée Smit, Aashley S.D. Sardjoe Mishre, Lisa L. Koorneef, Borja Martinez-Tellez, Jedrzej Burakiewicz, Hermien E. Kan, Floris H.P. van Velden, Lenka M. Pereira Arias-Boud Source Type: research