Correlations between disease activity, autoimmunity and biological parameters in patients with chronic spontaneous urticaria.

Conclusions. This study brings additional evidences of interest to investigate IgE, D-dimer serum/plasma levels and basophil blood counts in patients with CSU as they could be correlated to disease activity, response to treatment and/or autoimmunity. PMID: 31965967 [PubMed - as supplied by publisher]
Source: European Annals of Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

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Abstract Chronic urticaria is an uncommon disorder in children but can present considerable morbidity, as well as frustration for the healthcare provider and parent. The prevalence is 0.1-0.3% but can vary considerably by country. Chronic spontaneous urticaria (no identifiable cause) is responsible for 70-80% of chronic urticaria, about half of this due to a subtype called chronic autoimmune urticaria identified by the presence of autoantibodies to IgE or the IgE receptor. Chronic urticaria that is triggered by external physical stimuli is called chronic inducible urticaria and is present in another 15-20%. Allerg...
Source: Paediatric Drugs - Category: Pediatrics Authors: Tags: Paediatr Drugs Source Type: research
AbstractChronic urticaria is an uncommon disorder in children but can present considerable morbidity, as well as frustration for the healthcare provider and parent. The prevalence is 0.1 –0.3% but can vary considerably by country. Chronic spontaneous urticaria (no identifiable cause) is responsible for 70–80% of chronic urticaria, about half of this due to a subtype called chronic autoimmune urticaria identified by the presence of autoantibodies to IgE or the IgE receptor. Chron ic urticaria that is triggered by external physical stimuli is called chronic inducible urticaria and is present in another 15–2...
Source: Pediatric Drugs - Category: Pediatrics Source Type: research
Chronic spontaneous urticaria (CSU) is recurrent episodes of urticaria with or without angioedema for 6 weeks or longer due to unknown (nonphysical) causes.1 Although CSU tends to be self-limited in most patients, it has still been shown to markedly affect quality of life.1 The most recent data suggest a 0.5-1% prevalence of CSU in the general population.2 The trigger for CSU is often not known; but there is an association with autoimmune disease.3-5 The treatment includes up to four times (4x) standard dosing of second-generation long-acting H1 antihistamines, short-acting H1 antihistamines, H2 antihistamines, and/or leuk...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
Chronic spontaneous urticaria (CSU) involves recurrent episodes of urticaria with or without angioedema for 6 weeks or longer from unknown (nonphysical) causes.1 Although CSU tends to be self-limited in most patients, it still markedly affects quality of life.1 The most recent data suggest a 0.5% to 1% prevalence of CSU in the general population.2 The trigger for CSU is often not known, but there is an association with autoimmune disease.3-5 The treatment includes up to 4 times the standard dosing of second-generation long-acting histamine1 (H1) –antihistamines, short-acting H1-antihistamines, histamine2 (H2)–a...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
Acquired angioedema (AAE) is a rare disorder characterized by recurrent episodes of swelling without hives and C1 esterase inhibitor deficiency. Although clinically it presents similarly to hereditary angioedema, AAE generally develops in older patients and is associated with underlying disease, most notably lymphoproliferative disorders and autoimmune conditions.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
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Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized allergies health onetime syndication Source Type: news
Mast cells (MCs) are capable of executing powerful inflammatory response programs triggered by surface IgE cross-linking or through pattern recognition receptors. The question of how MCs contribute to human disease has been intensely investigated and stimulated much controversy. Correlative evidence comes from human studies, pointing to pathogenetic or protective MC functions in patients with atopic conditions, autoimmune disorders, type 2 diabetes, chronic urticaria, mastocytosis, and cancer. Experiments in MC-deficient mice underpinned key roles for MCs in patients with IgE-mediated allergic conditions.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Mast cells are capable of executing powerful inflammatory response programs triggered by surface IgE crosslinking or via pattern recognition receptors. The question of MC contributions to human disease has been intensely investigated and stimulated much controversy. Correlative evidence comes from human studies, pointing to pathogenetic or protective MC functions in atopic conditions, autoimmune disorders, type 2 diabetes, chronic urticaria, mastocytosis and cancer. Experiments in MC-deficient mice underpinned key roles for MCs in IgE-mediated allergic conditions.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Many autoimmune skin diseases, such as bullous pemphigoid (BP), psoriasis and certain types of chronic urticaria, are associated with intensive pruritus. While histamine and neuropeptides have previously been ascribed to play a role in itch that accompanies these diseases, recent evidence suggests that the pruritogenic cytokine interleukin (IL)-31 is a major driver of pruritic responses. IL-31 was originally shown to be produced by activated helper T cells, particularly Th2 cells, mast cells, macrophages and dendritic cells. However, more recent evidence demonstrated that eosinophils are a major source of this cytokine too...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Shanshan Zhang1, Dongli Yuan2 and Ge Tan1* 1Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 2The Institute of Medical Information, Chongqing Medical University, Chongqing, China Primary systemic vasculitis can affect every structure in both the central and peripheral nervous system, causing varied neurological manifestations of neurological dysfunction. Early recognition of the underlying causes of the neurological symptoms can facilitate timely treatment and improve the prognosis. This review highlights the clinical manifestations of primary systemic vasc...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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