The effect of acute malnutrition on enteric pathogens, moderate-to-severe diarrhoea, and associated mortality in the Global Enteric Multicenter Study cohort: a post-hoc analysis

Publication date: February 2020Source: The Lancet Global Health, Volume 8, Issue 2Author(s): Kirkby D Tickell, Rumana Sharmin, Emily L Deichsel, Laura M Lamberti, Judd L Walson, A S G Faruque, Patricia B Pavlinac, Karen L Kotloff, Mohammod J ChistiSummaryBackgroundHost vulnerabilities associated with acute malnutrition could facilitate the ability of specific enteric pathogens to cause diarrhoea and associated mortality. Using data from the Global Enteric Multicenter Study, we assessed whether acute malnutrition modifies the association between common enteric pathogens and moderate-to-severe diarrhoea, and whether associations between enteric pathogens and death were modified by acute malnutrition.MethodsChildren with moderate-to-severe diarrhoea and age-matched and community-matched controls were included in this post-hoc analysis if their mid-upper arm circumference had been measured and if they were older than 6 months of age. Acute malnutrition was defined as mid-upper arm circumference below 12·5 cm, capturing both severe acute malnutrition (
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research

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Conclusion: Our results advance the current mechanistic understanding of the pseurotin-induced inhibition of IgE production in B-cells by linking the effect to STAT signaling, and associated modulation of B-cell proliferation and differentiation. Together with our finding that structurally simpler pseurotin analogs were able to reproduce the effects of natural pseurotins, the presented work has implications for the future research on these secondary metabolites in the context of allergic diseases.Graphical abstact
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 22 February 2020Source: Materials LettersAuthor(s): Li Chen, Hong Pan, Caifeng Zhuang, Mengyao Peng, Li ZhangAbstractTreatment against bacterial infection is of great significance for joint wound healing in medical nursing care. Thus, it is urgent to develop efficient antibacterial agent with excellent wound healing capability. In this research, a two-step strategy was employed for the development of novel chitosan scaffold reinforced by strontium doped TiO2 nanoparticles (CS/Sr-TiO2). The antibacterial activity of CS/Sr-TiO2 against Escherichia coli, and Staphylococcus aureus were evalua...
Source: Materials Letters - Category: Materials Science Source Type: research
Authors: Caixàs A, Villaró M, Arraiza C, Montalvá JC, Lecube A, Fernández-García JM, Corio R, Bellido D, Llisterri JL, Tinahones FJ Abstract The high prevalence of obesity in our environment, a chronic disease of complex management and responsible for multiple comorbidities, requires the implementation of coordination strategies in clinical care between primary care and specialist hospital units. In a cross-sectional care model, primary care physicians guide all therapeutic management related to obesity. Together with them, specialists in endocrinology and nutrition and other heal...
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
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Source: Biotechnology Progress - Category: Biotechnology Authors: Tags: RESEARCH ARTICLE Source Type: research
Publication date: May 2020Source: Biomedical Signal Processing and Control, Volume 59Author(s): Shaun M. Davidson, Vincent Uyttendaele, Christopher G. Pretty, Jennifer L. Knopp, Thomas Desaive, J. Geoffrey ChaseAbstractObjectiveSafe, effective glycaemic control (GC) requires accurate prediction of future patient insulin sensitivity (SI), balancing the risk of hyper- and hypo-glycaemia. The stochastic targeted (STAR) protocol combines a clinically validated metabolic model and SI metric with a risk-based stochastic approach to optimise patient specific insulin and feed rates. Validated virtual trials comparing a novel 3D st...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
Publication date: Available online 21 February 2020Source: Protein Expression and PurificationAuthor(s): Brett A. Beaupre, Joseph V. Roman, Graham R. MoranAbstractDihydropyrimidine dehydrogenase (DPD) catalyzes the reduction of uracil and thymine bases with electrons derived from NADPH. The mammalian DPD enzyme is a functional homodimer and has an elaborate cofactor arrangement. Two flavin cofactors (FAD and FMN) reside in two active site cavities that are separated by around 60 Å. The flavins are apparently bridged by four Fe4S4 clusters, two of which are provided by the partner protomer of the dimer. The study of...
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
This study demonstrated the electrospun fibrous mat with efficient on-demand antibacterial properties is promising for practical application in anti-infective therapy.Graphical abstract
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Publication date: Available online 1 October 2018Source: The Lancet Global HealthAuthor(s): Elizabeth T Rogawski, Jie Liu, James A Platts-Mills, Furqan Kabir, Paphavee Lertsethtakarn, Mery Siguas, Shaila S Khan, Ira Praharaj, Arinao Murei, Rosemary Nshama, Buliga Mujaga, Alexandre Havt, Irene A Maciel, Darwin J Operario, Mami Taniuchi, Jean Gratz, Suzanne E Stroup, James H Roberts, Adil Kalam, Fatima AzizSummaryBackgroundEnteropathogen infections in early childhood not only cause diarrhoea but contribute to poor growth. We used molecular diagnostics to assess whether particular enteropathogens were associated with linear g...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 1 October 2018Source: The Lancet Global HealthAuthor(s): James A Platts-Mills, Jie Liu, Elizabeth T Rogawski, Furqan Kabir, Paphavee Lertsethtakarn, Mery Siguas, Shaila S Khan, Ira Praharaj, Arinao Murei, Rosemary Nshama, Buliga Mujaga, Alexandre Havt, Irene A Maciel, Timothy L McMurry, Darwin J Operario, Mami Taniuchi, Jean Gratz, Suzanne E Stroup, James H Roberts, Adil KalamSummaryBackgroundOptimum management of childhood diarrhoea in low-resource settings has been hampered by insufficient data on aetiology, burden, and associated clinical characteristics. We used quantitative diagnosti...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 19 July 2015 Source:The Lancet Global Health Author(s): James A Platts-Mills, Sudhir Babji, Ladaporn Bodhidatta, Jean Gratz, Rashidul Haque, Alexandre Havt, Benjamin JJ McCormick, Monica McGrath, Maribel Paredes Olortegui, Amidou Samie, Sadia Shakoor, Dinesh Mondal, Ila FN Lima, Dinesh Hariraju, Bishnu B Rayamajhi, Shahida Qureshi, Furqan Kabir, Pablo P Yori, Brenda Mufamadi, Caroline Amour, J Daniel Carreon, Stephanie A Richard, Dennis Lang, Pascal Bessong, Esto Mduma, Tahmeed Ahmed, Aldo AAM Lima, Carl J Mason, Anita KM Zaidi, Zulfiqar A Bhutta, Margaret ...
Source: The Lancet Global Health - Category: Global & Universal Source Type: research
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