Safety, Tolerability, and Pharmacokinetics and Pharmacodynamics of TB31F

Condition:   Malaria,Falciparum Intervention:   Biological: TB31F Sponsors:   Radboud University;   The PATH Malaria Vaccine Initiative (MVI) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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This study aimed to evaluate in vivo antimalarial activity of zingerone (ZN), and its combination with dihydroartemisinin (DHA) against Plasmodium berghei infected mice. ZN was prepared and tested for acute oral toxicity according to the OECD guideline. In vivo antimalarial activity of different doses of ZN and combination with DHA were determined using the 4-day suppression test. The results showed that ZN was found to be safe and no mortality within the observation period, and the lethal dose might be greater than the limited dose of 1000 mg/kg. For in vivo antimalarial test, ZN exhibited significant (p 
Source: Parasitology International - Category: Parasitology Source Type: research
Publication date: March 2020Source: The Lancet Global Health, Volume 8, Issue 3Author(s): Charbel El Bcheraoui, Honoré Mimche, Yodé Miangotar, Varsha Sarah Krish, Faye Ziegeweid, Kris J Krohn, Martin Herbas Ekat, Jobert Richie Nansseu, Zacharie Tsala Dimbuene, Helen Elizabeth Olsen, Roger C K Tine, Christopher M Odell, Christopher E Troeger, Nicholas J Kassebaum, Tamer Farag, Simon I Hay, Ali H MokdadSummaryBackgroundPeer-reviewed literature on health is almost exclusively published in English, limiting the uptake of research for decision making in francophone African countries. We used results from the Globa...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
[allAfrica] Cape Town -AllAfrica's Juanita Williams talked with Mark Suzman, the CEO of the Bill and Melinda Gates Foundation, the world's largest philanthropy. He assumed the position this month. In this second part of the interview, he discussed how his early career as a journalist in his native South Africa influences his perspectives; about the possibilities of eliminating malaria and reducing HIV, TB and other diseases; addressing hunger and undernutrition amid the climate crisis; and the biggest challenges he faces. Part 2
Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news
An acute episode of malaria can be followed by multiple recurrent episodes either due to re-infection, recrudescence of a partially treated parasite or, in the case of Plasmodium vivax or P. ovale, relapse from t...
Source: BMC Medicine - Category: Internal Medicine Authors: Tags: Research article Source Type: research
ConclusionThe rate of uptake of optimal doses of IPTp-SP among pregnant women at Trauma and Orthopaedic Hospital, Winneba was relatively high. Marital status, religion, educational level, employment, parity, and knowledge of malaria treatment and side effects of IPTp-SP were statistically significantly  associated with the uptake of IPTp-SP. In light of these findings, it is recommended that the Ministry of Health, National Malaria Control Programme, Ghana Health Service, and other stakeholders consider these factors when planning and carrying out programs geared towards improving the uptake of I PTp-SP among pregnant...
Source: Journal of Public Health - Category: Health Management Source Type: research
Authors: Nkoy AB, Ndiyo YM, Matoka TT, Odio BM, Kazadi OK, Aloni MN, Collard L, McCulloch M, Ngiyulu RM, Gini JE, Lepira FB, van den Heuvel LP, Levtchenko E, Ekulu PM Abstract In the Democratic Republic of Congo (DRC), acute kidney injury (AKI) contributes to the high rate of child mortality owing to the conjunction of poverty, deficiency of qualified health-care providers in pediatric nephrology, and the lack of pediatric dialysis programs. We aimed to describe the recent experience of the first pediatric acute peritoneal dialysis (PD) program in DRC. This is a retrospective cohort study on epidemiology, clinical ...
Source: Peritoneal Dialysis International - Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research
Funding Opportunity RFA-AI-20-021 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement is to solicit applications for the Vaccine and Treatment Evaluation Units (VTEUs) to implement clinical site protocols (clinical research, clinical trials) for evaluating vaccines, other preventive biologics, therapeutics, diagnostics, including prognostic and predictive markers, and devices for the treatment and prevention of infectious diseases as part of NIAID Infectious Diseases Clinical Research Consortium (IDCRC). A companion FOA solicits applications for the Leadership Group for the In...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Plasmodium vivax is the most widespread human malaria parasite outside Africa and is the predominant parasite in the Americas. Increasing reports of P. vivax disease severity, together with the emergence of drug-...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
According to the World Health Organization reports, billions of people around the world are at risk for malaria disease and it is important to consider the preventive strategies for protecting the people that ...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
ConclusionsThis study of adult African in-patients with falciparum malaria with and without HIV co-infection, neither confirms nor rejects previous studies of malaria qPCR in plasma as an indicator of disease severity in patients with falciparum malaria. There is a need for further and larger studies to clarify if parasitemia as assessed malaria qPCR in plasma could be a surrogate marker of disease severity in falciparum malaria.
Source: Infection - Category: Infectious Diseases Source Type: research
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