HIV/AIDS and the Tumor Niche (U54 Clinical Trial Not Allowed)

Funding Opportunity RFA-CA-20-016 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to advance our understanding of the role of the tumor niche or microenvironment in the risks, development, progression, and diagnosis of cancer observed in individuals with an underlying HIV infection or Acquired Immune Deficiency Syndrome (AIDS). The proposed research areas identify two main areas that most likely control the major activities for establishing and maintaining the tumor niche: the role of the AIDS retrovirus and the response of the host to HIV infection. These areas of research will advance our understanding of the contribution to the tumor niche in the context of an underlying HIV infection.
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding

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The President has proposed a $38.7 billion budget for the National Institutes of Health in fiscal year (FY) 2021. This translates to a $3 billion or 7 percent cut in the agency’s funding compared to FY 2020. The NIH budget request includes a $50 million initiative to use artificial intelligence (AI) to develop a better understanding of the causes of chronic diseases and to identify early treatments. This plan is in line with the Administration’s “Industries of the Future” effort, which supports using and developing AI across sectors. The budget would provide $50 million for the Childhood Cancer ...
Source: Public Policy Reports - Category: Biology Authors: Source Type: news
By Casey Bishopp, Communications officer, IntraHealth International ; Sabra Farquharson, Business development officer, IntraHealth InternationalFebruary 18, 2020We’re celebrating the legacies of ten African Americans in public health this month—shining a light on the invaluable contributions made by these scholars and health workers. According to themost recent report form the Health Resources and Services Administration, African Americans make up 11.6% of the US health workforce, and throughout American history have made invaluable contributions to greater public health in fields s...
Source: IntraHealth International - Category: International Medicine & Public Health Authors: Source Type: news
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Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
Abstract Osteosarcoma is an aggressive bone cancer found in children and adolescents. The surgical removal of tumour and chemotherapy combined treatment for osteosarcoma has been widely accepted approach. However, the drug resistance developed by tumour cells resulted in recurrence of cancer. It is imperative to understand the molecular mechanism involved in the development of drug resistance and tumour progression for developing potential therapy. Tumour microenvironment and cellular cross talk via activation of various signalling pathways are responsible for tumour progression and metastasis. The comprehend revi...
Source: Current Drug Metabolism - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Metab Source Type: research
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Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
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Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Medical Practice Physicians Burnout physician burnout physician wellness Sanj Katyal Source Type: blogs
AbstractPurpose of ReviewThis review summarizes recent literature defining tissue-resident memory T cells (TRM) and discusses implications for HIV pathogenesis, vaccines, and eradication efforts.Recent FindingsInvestigations using animal models and human tissues have identified a TRM transcriptional profile and elucidated signals within the tissue microenvironment leading to TRM development and maintenance. TRM are major contributors to host response in infectious diseases and cancer; in addition, TRM contribute to pathogenic inflammation in a variety of settings. Although TRM are daunting to study in HIV infection, recent...
Source: Current HIV/AIDS Reports - Category: Infectious Diseases Source Type: research
Publication date: Available online 7 February 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): S.G. Brouwer de Koning, M.B. Karakullukcu, C.A.H. Lange, W.H. Schreuder, L.H.E. Karssemakers, T.J.M. RuersAbstractWe wanted to find out whether ultrasound (US) can be used to assess the deep resection margins after excision of squamous cell carcinoma (SCC) of the tongue, as intraoperative feedback on their condition might help to prevent them being too close. Resected specimens of cancers of the tongue from 31 patients with SCC of the tongue were suspended in US gel and scanned with a small 5-10 MHz US...
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
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Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Health Policy Patients Research Patient Council of the Right Care Alliance Patient Experience Source Type: blogs
Norval Skin cancer is a non-communicable disease that has been underexplored in Africa, including Southern Africa. Exposure to solar ultraviolet radiation (UVR) is an important, potentially modifiable risk factor for skin cancer. The countries which comprise Southern Africa are Botswana, Lesotho, Namibia, South Africa, and Swaziland. They differ in population size and composition and experience different levels of solar UVR. Here, the epidemiology and prevalence of skin cancer in Southern African countries are outlined. Information is provided on skin cancer prevention campaigns in these countries, and evidence sought...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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