Numerical analysis of apparent decitabine uptake in HCT116 cells: Incorporation of a bidirectional first-order kinetic parameter for ENT1 transport and Michaelis-Menten parameters for subsequent phosphorylation.

In conclusion, DAC uptake mainly via ENT1 may be described by a bidirectional first-order kinetic parameter, while phosphorylation by dCK may be described by Michaelis-Menten parameters. PMID: 31964620 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31964620?dopt=Abstract

Source: Drug Metabolism and Pharmacokinetics - January 24, 2020 Category: Drugs & Pharmacology Tags: Drug Metab Pharmacokinet Source Type: research