Prolonged QT interval in oncology

As we have learned more about the relationship of some medications to prolonged QT interval and the risk a prolonged QT interval presents for torsade de pointes, ventricular tachycardia, and sudden death, there is more concern about which patients are at highest risk and how to prevent arrhythmia. There are medications used in oncology patients that are associated with prolongation of the QT interval. In this volume of The Journal, Lim et al reviewed a single center experience with respect to these issues in hospitalized oncology patients.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: The Editors' Perspectives Source Type: research

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The Preventive Ablation of Ventricular Tachycardia in Patients with Myocardial Infarction (BERLIN VT) trial investigators (Willems et  al; Circulation 2020;Epub ahead of print, PMID 32000514) sought to assess the effect of timing of ablation for ventricular tachycardia (VT) in patients with previous myocardial infarction (MI). In this randomized trial conducted at 26 European centers, patients with history of previous MI and left ventricular ejection fraction 30%–50% who presented with life-threatening ventricular arrhythmias necessitating implantable cardioverter–defibrillator (ICD) implantation were rand...
Source: Heart Rhythm - Category: Cardiology Authors: Tags: EP News Source Type: research
In conclusion, right ventricular dimensions are the most significant factors associated with the development of VA in TOF. The number of surgical interventions is also related to an increased risk.
Source: Pediatric Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 13 February 2020Source: Journal of Clinical NeuroscienceAuthor(s): Takashi Shimoyama, Hiroshi Hayashi, Fumiaki Suzuki, Yasuhiro Nishiyama, Yoshihiro Miyamoto, Takeshi Aiba, Wataru Shimizu, Kazumi KimuraAbstractMyotonic dystrophy type 1 (DM1) is an autosomal dominant inherited muscular dystrophy caused by an expanded CTG repeat in the dystrophia myotonica protein kinase (DMPK) gene. Cardiac involvements in DM1 are characterized by cardiac conduction delays and atrial or ventricular tachycardia, which increase the risk of sudden cardiac death when compared with general population. Only a fe...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
CONCLUSION: Real-time tracking and beam-gating were successfully applied in this first MRgRA to treat sustained VT. PMID: 32067819 [PubMed - as supplied by publisher]
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
Ventricular tachycardia (VT) is a life-threatening sequela found in patients with cardiomyopathy.
Source: Radcliffe Cardiology - Category: Cardiology Authors: Source Type: research
In the article by Tilz et al. entitled “Preventive Ventricular Tachycardia Ablation in Patients With Ischaemic Cardiomyopathy: Meta-analysis of Randomised Trials” (Arrhythmia&Electrophysiology Review 2019;8(3):173 –9., the following correction should be made:
Source: Radcliffe Cardiology - Category: Cardiology Authors: Source Type: research
Abstract Chronic Chagas heart disease has different clinical manifestations including arrhythmias, heart failure, and stroke. Chest pain is one of the most common symptoms and when associated with changes in the electrocardiogram, such as T-wave changes, electrically inactive areas, and segmental wall motion abnormalities, may lead to a misdiagnosis of acute coronary syndrome (ACS). Here, we describe two patients with Chagas heart disease and syncope due to sustained ventricular tachycardia who were misdiagnosed with ACS, and discuss the role of novel imaging modalities in the differential diagnosis and risk strat...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
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Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: EDITORIAL ‐ INVITED Source Type: research
ConclusionDex conferred anti-arrhythmic effects in the context of ICM via upregulation of Cx43 and suppression of inflammation and fibrosis. The anti-arrhythmic and anti-inflammatory properties of Dex may be mediated by phosphorylation of AMPK and subsequent suppression of NF-κB activation.
Source: Frontiers in Physiology - Category: Physiology Source Type: research
AbstractAcute management of patients with ventricular arrhythmia (VA) is aimed at immediate VA termination if the patient is hemodynamically instable and early termination after initial diagnostic work-up if tolerated. Prolonged episodes of VA may lead to hemodynamic and metabolic decompensation and early resumption of normal ventricular activation is warranted. Termination is best performed by electrical cardioversion, anti-tachycardia pacing (if available, in cases with an implanted defibrillator [ICD]) or defibrillation. Antiarrhythmic drug treatment may lead to rhythm stabilization in cases of VA recurrence. Scrutinizi...
Source: Herzschrittmachertherapie und Elektrophysiologie - Category: Cardiology Source Type: research
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