Frequency and characteristics of congenital intraspinal abnormalities in a cohort of 128 patients with congenital scoliosis
Conclusions: Our study showed a lower percentage of spinal anomalies compared to other series. As other studies, the progression of the scoliosis curve in patients with spinal anomalies seems primarily to be determined by the type of vertebral malformation. Level of Evidence: Level II.
Authors: Nambiar PN, Kumar S S, Menon R, Nair SS, Madhavilatha GK, Sundaram S PMID: 32077773 [PubMed - as supplied by publisher]
This study aimed to determine the mechanism by which melatonin inhibits the proliferation of osteoblasts.Main methodsCell viability experiment, DNA fragment detection and alkaline phosphatase (ALP) activity assays were performed to determine the effects of melatonin on the proliferation, apoptosis and differentiation of osteoblasts. We used immunofluorescence to detect the expression of STIM1 in melatonin-treated osteoblasts. STIM1 interference was achieved using a specific siRNA, and a TRPC inhibitor was used to block the influx of Ca2+. The mRNA expression was determined by RT-qPCR, and protein levels were measured by We...
This article summarizes the best available evidence interventions for preventing and managing cerebral palsy in 2019.Recent FindingsEffective prevention strategies include antenatal corticosteroids, magnesium sulfate, caffeine, and neonatal hypothermia. Effective allied health interventions include acceptance and commitment therapy, action observations, bimanual training, casting, constraint-induced movement therapy, environmental enrichment, fitness training, goal-directed training, hippotherapy, home programs, literacy interventions, mobility training, oral sensorimotor, oral sensorimotor plus electrical stimulation, pre...
Spinal muscular atrophy (SMA) is among the most common monogenic causes of spinal motor neuron(SMN) degeneration with severely affected cases having a median survival of less than 2 years of age. Nusinersen (Spinraza) is a novel antisense oligonucleotide administered intrathecally for treatment of SMA. Most of these patients have scoliosis often treated by posterior fusion from T2 to sacrum making lumbar puncture challenging. Building on our prior experience in intrathecal catheter placement, we describe our initial experience with an image-guided approach to implantation of intrathecal catheters and subcutaneous ports in ...
Angoori Gnaneshwar Rao, V Srikanth Reddy, M Divya Parimala, M Tejal, Kousar Fathima, Sunki Preeti, Jayasree Jhawar, Vidya Dharani, T ShruthiIndian Journal of Dermatology, Venereology, and Leprology 2020 86(2):187-190
Conclusions: Even with the absence of subjective urinary symptoms, subclinical urologic impairments can be observed in a significant number of patients with ISC. An abnormal UDS finding can be a sign of underlying spinal cord tethering in a patient with ISC who is a candidate for corrective spine surgery even though it is an independent variant and is not exclusive to candidates for surgery. This finding has high clinical utility for neuro- and ortho-spine surgeons who aim to correct scoliosis (OR, 4.2; p =0.009). PMID: 32066207 [PubMed - as supplied by publisher]
ConclusionAIS patients showed more slender spines than the asymptomatic population. Analysis of wedging suggests that lower junctional discs and apex vertebra could be locations of mechanical instability. Numerical simulation and longitudinal clinical follow-up of patients could clarify the impact of wedging, slenderness and growth on the biomechanics of scoliosis progression.Graphic abstractThese slides can be retrieved under Electronic Supplementary Material.
CONCLUSIONS: Cumulative radiation dose during scoliosis treatment varies substantially depending on radiographic follow-up protocol, intraoperative and ancillary imaging. By using low-dose X-ray systems in combination with a low-dose protocol for intraoperative navigation, it is possible to keep exposure to patients at a minimum while still providing optimal care. FUNDING: none. TRIAL REGISTRATION: not relevant. PMID: 32053488 [PubMed - in process]
Authors recommend that surgeons gradually stretch the spine when using the magnetic rod system in kids with scoliosisMedscape Medical News
Publication date: Available online 12 February 2020Source: Annals of Physical and Rehabilitation MedicineAuthor(s): Dominic Pérennou, Marie Jaeger, Bettina Debu, Valérie Fraix, Adelaide Marquer, Paul Krack, Céline Piscicelli, Anna Castrioto