Multidimensional Studies of Pancratium parvum Dalzell Against Acetylcholinesterase: A Potential Enzyme for Alzheimer ’s Management

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Source: Journal of the American College of Nutrition - Category: Nutrition Authors: Source Type: research

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ConclusionsBased on these results, we suggest that DSS play a positive effective role in increasing DHA content by up-regulating iPLA2 and 15-LOX, resulting in ameliorating oxidative stress and inflammation and finally ameliorating cognition deficits in APP/PS1 mice.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS The results indicate that, although persons with disabilities can exhibit a wide functional range, they remain at risk of PUs and should be evaluated for proper preventive measures, including support surfaces and wheelchair cushions.
Source: Advances in Skin and Wound Care - Category: Dermatology Tags: ORIGINAL INVESTIGATION Source Type: research
Publication date: 1 April 2020Source: Journal of Molecular Liquids, Volume 303Author(s): Faisal Ameen, Sharmin Siddiqui, Ishrat Jahan, Shahid M. Nayeem, Sayeed ur Rehman, Mohammad TabishAbstractMemantine is an NMDA receptor antagonist used to treat Alzheimer's disease. Detailed insight about the interaction between memantine and bovine serum albumin (BSA) was obtained through multi spectroscopic techniques and in silico analysis. UV–visible, steady-state fluorescence spectra, and resonance light scattering (RLS) studies showed the complex formation between memantine and BSA. The binding constant for the BSA-memantine...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
(American Chemical Society) It seems too good to be true: a single drug that could treat humanity's worst afflictions, including atherosclerosis, cancer, Alzheimer's, Parkinson's and arthritis. All of these diseases have one thing in common -- they involve an inflammatory protein called NLRP3. Now, biotech start-ups and pharmaceutical companies are racing to develop drugs that inhibit the function of this protein, according to an article inChemical&Engineering News (C&EN), the weekly newsmagazine of the American Chemical Society.  
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Contributors : Chin-Tong Ong ; Swarnaseetha AdusumalliSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterIntron retention (IR) may affect gene expression and protein functions during development and age-onset diseases. However, it remains unclear if IR undergoes spatial or temporal changes during different stages of ageing or neurodegenerative disorders like Alzheimer ’s disease (AD). By profiling mRNA species across different ages of Drosophila heads, we observed significant increase in the level of IR of many conserved genes as animals aged. Interestingly, distinct set...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Drosophila melanogaster Source Type: research
AbstractThe classic neuropathological features of Alzheimer's disease (AD) are accompanied by other complications, including alterations in adult cell proliferation and neurogenesis. Moreover, recent studies have shown that traditional markers of the neurogenic process, such as doublecortin (DCX), may also be expressed in CD8+ T cells and ionized calcium binding adaptor molecule 1 (Iba1+) microglia, in the close proximity to senile plaques, increasing the complexity of the condition. Altered glucose tolerance, observed in metabolic alteratioins, may accelerate the neurodegenerative process and interfere with normal adult c...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research
Multiple national expert panels have identified early detection of Alzheimer ’s disease and related dementias (ADRD) as a national priority. However, the United States Preventive Services Task Force (USPSTF) do...
Source: Trials - Category: General Medicine Authors: Tags: Study protocol Source Type: research
ConclusionsFurther investigations are necessary to better evaluate the potential cognitive-enhancing role of intranasal insulin in the Down syndrome population.ClinicalTrials.gov IDNCT02432716.
Source: Drugs in R&D - Category: Drugs & Pharmacology Source Type: research
ConclusionThese findings provide further support that race modifies the AD phenotypes downstream from cerebral amyloid deposition, and identifies key inter-subsystem connections for deep imaging and neuropathologic characterization.
Source: Translational Neurodegeneration - Category: Neurology Source Type: research
When PET scans reveal elevated amyloid levels in cognitively normal older adults,...Read more on AuntMinnie.comRelated Reading: FDG-PET shows where exercise could stall Alzheimer's PET, MRI link amyloid plaque with swift decline Who should get brain scans for Alzheimer's disease? PET, MRI show physical activity aids brain health Would high amyloid level spur physician-assisted death?
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
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