Endotoxin Removal in Septic Shock with the Alteco ® LPS Adsorber was Safe But Showed No Benefit Compared to Placebo in the Double-Blind Randomized Controlled Trial - the Asset Study.

Lipopolysaccharides (LPS) are presumed to contribute to the inflammatory response in sepsis. We investigated if extracorporeal Alteco ® LPS Adsorber for LPS removal in early Gram-negative septic shock was feasible and safe. Also, effect on endotoxin level, inflammatory response and organ function were assessed. In a small cohort of patients with presumed Gram-negative septic shock, levels of circulating endotoxin were low and no adverse effects within 28 days after LPS adsorber-treatment were observed. No benefit compared to a sham device was seen when using a LPS adsorber in addition to standard care.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
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