Health comorbidities and cognitive abilities across the lifespan in Down syndrome

ConclusionsOur results indicate the prevalence of multiple comorbidities varies across the lifespan in DS, and in adults, rates for psychiatric comorbidities show different patterns for males and females relative to expected population rates. Further, most health comorbidities are not associated with poorer cognitive outcomes in DS, apart from autism and epilepsy. It is essential for clinicians to consider such differences to provide appropriate care and treatment for those with DS and to provide prognostic information relating to cognitive outcomes in those with comorbidities.
Source: Journal of Neurodevelopmental Disorders - Category: Neurology Source Type: research

Related Links:

Publication date: Available online 19 February 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Konstantinos Palikaras, Nektarios TavernarakisAbstractMaintenance of synaptic homeostasis is a challenging task, due to the intricate spatial organization and intense activity of synapses. Typically, synapses are located far away from the neuronal cell body, where they orchestrate neuronal signalling and communication, through neurotransmitter release. Stationary mitochondria provide energy required for synaptic vesicle cycling, and preserve ionic balance by buffering intercellular calcium at synapses. Thus, synaptic h...
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research
CONCLUSIONS: Care teams need to offer opportunities to elicit patients' knowledge and fears, dispel myths, forge connections with other patients, and visit the dialysis unit before transition to alleviate anxiety. Interventions that facilitate a sense of control should be grounded in the meaning that the disorder has for the person and how it impacts their sense of self. PMID: 32063183 [PubMed - as supplied by publisher]
Source: Peritoneal Dialysis International - Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research
CONCLUSIONS The results indicate that, although persons with disabilities can exhibit a wide functional range, they remain at risk of PUs and should be evaluated for proper preventive measures, including support surfaces and wheelchair cushions.
Source: Advances in Skin and Wound Care - Category: Dermatology Tags: ORIGINAL INVESTIGATION Source Type: research
Excessive masculinity is linked to a significantly increased risk for death by suicide in men, a finding that underscores the central role of gender in suicide death, new research shows.Medscape Medical News
Source: Medscape Emergency Medicine Headlines - Category: Emergency Medicine Tags: Psychiatry News Source Type: news
AbstractBackgroundLimited studies are available on the clinical significance of left ventricular lead polarity in patients undergoing cardiac resynchronization (CRT), with a recent study suggesting better outcomes with LV true bipolar pacing.ObjectivesWe aimed to determine whether True ‐Bipolar LV pacing is associated with reduced mortality in a large, real‐life CRT cohort, followed by remote monitoring.MethodsWe analyzed de ‐identified device data from CRT patients followed by the Boston Scientific LATITUDE remote monitoring database system. Patients with LV bipolar leads paced between the LV ring and LV tip were id...
Source: Pacing and Clinical Electrophysiology : PACE - Category: Cardiology Authors: Tags: ELECTROPHYSIOLOGY Source Type: research
Authors: Barata AN Abstract Globally, the world population is ageing, which increases the prevalence of non-communicable diseases that affect patients both physically and psychologically, such as is the case of dementia. Consequently, there is a greater demand for the healthcare system as it needs to develop solutions to answer to these needs.The literature review shows that complementary therapies may be applied in dementia in order to aid the symptom management as well as to slow down the progression of the disease. The Socially Assistive Robots (SAR) are tools that may be used as a complementary therapy in demen...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
We examined the current studies on the efficiency and effectiveness of the robot interventions and produced a taxonomy of the review. An original finding of the current robotics in rehabilitation landscaping are critical presented with recommendations and concluding remarks concerning interdisciplinary impact. PMID: 32067201 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
In this study, 91 adolescents (10-24 years; 78 females) including 30 chronic pain patients with high pain-related distress, 29 chronic pain patients with low pain-related distress, and 32 healthy peers without chronic pain completed a developmentally appropriate T–S learning paradigm. We measured self-reported fear, psychophysiology (skin conductance response), and functional magnetic resonance imaging responses (N = 72 after functional magnetic resonance imaging exclusions). After controlling for age and anxiety symptoms, patients with high pain-related distress showed altered self-reported fear and frontolimbic act...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Drawing on advances in chronic pain metrics, a simplified Graded Chronic Pain Scale-Revised was developed to differentiate mild, bothersome, and high-impact chronic pain. Graded Chronic Pain Scale-Revised was validated among adult enrollees of 2 health plans (N = 2021). In this population, the prevalence of chronic pain (pain present most or every day, prior 3 months) was 40.5%: 15.4% with mild chronic pain (lower pain intensity and interference); 10.1% bothersome chronic pain (moderate to severe pain intensity with lower interference with life activities); and 15.0% high-impact chronic pain (sustained pain-related activit...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
“Asymbolia for pain” has shown the potentiality of diseased insular networks to dissociate sensory from affective-behavioral dimensions of pain, resulting in the lack of appropriate motor and affective responses despite preserved sensory aspect of pain. Here, we describe 4 patients with an inverse phenomenon of asymbolia for pain, namely an isolated “symbolism for pain” triggered by epileptic seizures, characterized by pain behavior without declarative pain sensation despite fully preserved contact and vigilance. Stereoelectroencephalography demonstrated in each case focal seizure discharges within ...
Source: Pain - Category: Anesthesiology Tags: Clinical Note Source Type: research
More News: ADHD | Anxiety | Autism | Bipolar | Brain | Cardiology | Dementia | Depression | Disability | Down's Syndrome | Epilepsy | Heart | Mania | Neurology | Psychiatry | Schizophrenia | Wales Health