Angiotensin Receptor Blockers and the Risk of Suicide: An Exercise in the Critical Examination of a Case-Control Study.

Angiotensin Receptor Blockers and the Risk of Suicide: An Exercise in the Critical Examination of a Case-Control Study. J Clin Psychiatry. 2020 Jan 21;81(1): Authors: Andrade C Abstract Angiotensin receptor blockers (ARBs), used in the treatment of hypertension, may modulate neurotransmission in the central nervous system. One previous very small case-control study had suggested that ARBs increase the odds of suicide. In a recent, large, population-based, nested case-control study conducted in Ontario, Canada, completed suicide was associated with significantly increased odds of an ARB prescription during the 100 days preceding the suicide; in this analysis, confounding by indication was reduced by comparing ARB exposure with angiotensin-converting enzyme inhibitor exposure. The results of this new study were widely disseminated in the scientific and mass media. However, at least some of the data presented in the study appeared implausible, and at least one important calculation was incorrect. Furthermore, important subgroup analyses were not conducted. These incongruities diminish the confidence of the reader in the data and in the analyses presented in the study. A generous conclusion is that, at best, ARB use is a marker of suicide risk that merits examination in studies that include a follow-up, in which absolute risks and dose-dependent and treatment duration-dependent effects can be examined. A parsimonious conclusion is that there is no association...
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

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This is the latest in a series of yearly posts in which I suggest areas of development for biotech startups I'd like to see actively developed as a part of the longevity industry in the near future. Today, this year, is a good time to be starting a company focused on the production of a novel therapeutic approach to intervening in the aging process. There is a great deal of funding for seed stage investment, and many compelling projects lacking champions, yet to be carried forward from academia into preclinical development. Numerous scientific and industry crossover conferences are now held every year, at which it is possi...
Source: Fight Aging! - Category: Research Authors: Tags: Investment Source Type: blogs
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Addiction Health Health care disparities Men's Health Women's Health Source Type: blogs
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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Aging Depression depression risk Elderly seniors Source Type: blogs
Angiotensin receptor blockers (ARBs), used in the treatment of hypertension, may modulate neurotransmission in the central nervous system. One previous very small case-control study had suggested that ARBs increase the odds of suicide. In a recent, large, ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
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Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research
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Source: Psychiatr News - Category: Psychiatry Tags: antipsychotics death Heidi Taipale hospitalization long-term use schizophrenia side effects suicide World Psychiatry Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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