Steroidal saponins from Trillium tschonoskii rhizomes and their cytotoxicity against HepG2 cells

Publication date: Available online 23 January 2020Source: SteroidsAuthor(s): Yin-Jun Yang, Xu Pang, Bei Wang, Jie Yang, Xiao-Juan Chen, Xin-Guang Sun, Qi Li, Jie Zhang, Bao-Lin Guo, Bai-ping MaAbstractA phytochemical study on the rhizomes of Trillium tschonoskii led to the isolation of fourteen new steroidal saponins, trillitschosides S1-S14 (1–14), along with ten known analogues (15-24). Their structures were established mainly by spectroscopic analyses as well as necessary chemical evidence. All isolated compounds were screened for the cytotoxicity against HepG2 cells, and the results demonstrated that only the known compounds 21-24 exhibited the remarkable cytotoxic activity against HepG2 cells which is much better than the positive control of 5-FU.Graphical abstractA phytochemical study on the rhizomes of Trillium tschonoskii led to the isolation of fourteen new steroidal saponins (1-14), along with ten known analogues (15-24).
Source: Steroids - Category: Drugs & Pharmacology Source Type: research