Secoeudesma sesquiterpenes lactone A alleviates inflammation and offers adjuvant protection in severe infection of carbapenem-resistant Klebsiella pneumoniae

ConclusionAccording to the notable anti-inflammatory effect in vitro and its joint protective effects on a septic mouse model, SESLA might act as an adjuvant drug candidate for sepsis, even those caused by antibiotic-resistant bacteria, e.g., CRKP.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research

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Authors: Lai L, Lai Y, Wang H, Peng L, Zhou N, Tian Y, Jiang Y, Gong G Abstract Objective: Gram-negative bloodstream infections (GNBSIs), especially those caused by antibiotic-resistant species, have become a public health challenge. Procalcitonin (PCT) showed promising potential in early diagnosis of GNBSI; however, little was known about its performance under different clinical settings. We here systematically assessed the diagnostic accuracy of PCT in recognizing GNBSI and made direct comparisons with C-reactive protein (CRP) and interleukin 6 (IL-6). Methods: PubMed, Embase, ISI Web of Knowledge, and Scopus...
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
In conclusion, our results suggested that AVNP2 could have an effect on the peri-tumor environment, obviously restraining the growth progress of gliomas, and eventually improving cognitive levels in C6-bearing rats.
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Publication date: Available online 22 February 2020Source: Journal of Hospital InfectionAuthor(s): Sarah Jolivet, Isabelle Lolom, Sébastien Bailly, Lila Bouadma, Brice Lortat-Jacob, Philippe Montravers, Laurence Armand-Lefevre, Jean-François Timsit, Jean-Christophe LucetSummaryBackgroundColonisation pressure is a risk factor for intensive care unit (ICU)-acquired multidrug-resistant organisms (MDROs).AimTo measure the long-term respective impact of colonisation pressure on ICU-acquired extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) and meticillin resistant Staphylococcus aureus (MRS...
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
Empirical anti-MRSA treatment is associated with an increased risk of 30-day mortality in patients hospitalized for pneumonia, compared with standard antibiotic therapy, according to a retrospective study.Reuters Health Information
Source: Medscape Pathology Headlines - Category: Pathology Tags: Pulmonary Medicine News Source Type: news
ConclusionThe approach combining UHPLC-Q-Orbitrap HRMS with network pharmacology analysis is a rapid and effective tool to identify potentially bioactive constituents in medicinal plants and prescriptions.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionsChios mastic's beneficial properties have been demonstrated in the treatment of gastrointestinal disorders, wound healing, skin inflammations, plasma lipid and blood sugar reduction and oral care. These properties are attributed to triterpenes and volatile compounds. However, because of the resin's chemical complexity and the lack of commercial standards for its main compounds, there is a notable gap in literature concerning the biological evaluation of CMG's isolated components. Therefore, future research should focus on the development of efficient extraction, isolation and analysis techniques in order to unra...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
DiscussionThe results of this clinical trial will offer evidence for the efficacy and safety of Dangguijagyag-san for primary dysmenorrhea.Trial registrationClinical Research Information Service ( KCT0003005
Source: Integrative Medicine Research - Category: Complementary Medicine Source Type: research
Among the major drivers of the Antimicrobial Resistance crisis is the misuse and overuse of antibiotics in livestock and feed. Credit: Germán Miranda/IPS. By Tharanga YakupitiyageUNITED NATIONS, May 21 2019 (IPS) Antimicrobial resistance is quickly becoming a global crisis and risks reversing a century of progress in health. Some organisations have already geared up and are tackling the issue from its roots. In a new report, the United Nations Interagency Coordination Group (IACG) on Antimicrobial Resistance estimates that antibiotic resistance could cause 10 million deaths each year by 2050. Already, drug-resistan...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Development & Aid Featured Global Headlines Health IPS UN: Inside the Glasshouse North America Regional Categories Sustainability TerraViva United Nations Antimicrobial resistance (AMR) WHO Source Type: news
Although my father did not discover penicillin, he helped do the research showing its effectiveness in curing infective endocarditis. As an internist, he then became enamored with the role antibiotics could play in treating infections. Growing up, my siblings and I can attest to his unbridled enthusiasm, as every time we contracted a cold, we would get a shot of the wonder mold in our butts. The fact that colds were caused by viruses and not bacteria did little to dissuade him from the utility of the treatment. When I finally developed a rash after another shot, I celebrated the fact that the painful solution would never e...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Physician Infectious Disease Primary Care Source Type: blogs
It was February, and clinic was teeming with respiratory infections of all kinds: mostly the common cold, but also bronchitis, pneumonia, and sinus infections. The first patient on my schedule was a healthcare provider with “sinus infection” written down as her main issue.* She’d had about two weeks of nasal and sinus congestion which she blamed on a viral upper respiratory infection (URI, also known as the common cold). Her two young kids had been sick with colds all winter, so she wasn’t surprised to have these symptoms, along with endless postnasal drip and a cough. Her congestion had improved a ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Asthma and Allergies Cold and Flu Drugs and Supplements Infectious diseases sinus infection Source Type: blogs
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