Smad2 linker region phosphorylation is an autonomous cell signalling pathway: Implications for multiple disease pathologies

Publication date: April 2020Source: Biomedicine & Pharmacotherapy, Volume 124Author(s): Danielle Kamato, Peter J. LittleAbstractThis review will cover the signalling pathways leading to the phosphorylation of the Smad linker region independent of Smad carboxy terminal phosphorylation. Characterising Smad linker region as a signalling pathway in its own right will encourage comprehensive signalling studies to provide solutions for successful discovery and exploitation of drug targets. The review describes Smad transcription factor signalling distinct from Transforming Growth Factor (TGF)-β signalling. Novel signalling pathways represent new drug targets where these pathways are known to be involved in fibrosis, cancer and cardiovascular disease.Graphical abstract
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research