Familial hypercholesterolaemia: evolving knowledge for designing adaptive models of care

Nature Reviews Cardiology, Published online: 23 January 2020; doi:10.1038/s41569-019-0325-8Familial hypercholesterolaemia is a genetic disorder that impairs the hepatic clearance of LDL, leading to premature atherosclerotic cardiovascular disease. In this Review, Watts and colleagues summarize the latest advances that can inform the development and implementation of new models of care for familial hypercholesterolaemia.
Source: Nature Reviews Cardiology - Category: Cardiology Authors: Source Type: research

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In this study, we first analyzed the chemical compounds of AG by HPLC-DAD-ESI-IT-TOF-MS n . Of the 31 compounds detected, 29 were identified based on previous results. Then, the effects of DMY and AG on high-fat diet hamster livers were studied and the metabolite levels and metabolic pathway activity of the liver were explored by 1H NMR metabolomics. Compared to the high-fat diet group, supplementation of AG and DMY attenuated the high-fat-induced increase in body weight, liver lipid deposition, serum triglycerides and total cholesterol levels, and normalized endogenous metabolite concentrations. PCA and PLS-DA score plots...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Conclusion: The study shows that the metabolomic method may be a valuable tool for studying the essence of toxicity induced by traditional Chinese medicine. PMID: 32071608 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Publication date: May 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 189Author(s): Shima Rahim Pouran, Abolfazl Bayrami, Farid Mohammadi Arvanag, Aziz Habibi-Yangjeh, Reza Darvishi Cheshmeh Soltani, Ramesh Singh, Abdul Aziz Abdul Raman, Keun Hwa Chae, Alireza Khataee, Hee Kyoung KangAbstractIn this research, a milk thistle seed extract (MTSE)-rich medium was used as a capping and reducing agent for the one-pot biosynthesis of ZnO/Ag (5 wt%) nanostructure. The sample was systematically characterized through various techniques and its strong biomolecule‒metal interface structure was supported by the results. ...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Conditions:   Cholesterol, Elevated;   Overweight or Obesity Interventions:   Dietary Supplement: RS4 bar;   Dietary Supplement: Control bar Sponsors:   Kansas State University;   MGP Ingredients, Inc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 18 February 2020Source: Journal of the Formosan Medical AssociationAuthor(s): Fang-Ju Lin, Kou-Gi Shyu, I-Chang Hsieh, Wayne Huey-Herng Sheu, Shih-Te Tu, Shoou-Jeng Yeh, Chin-I Chen, Kuo-Cheng Lu, Chia-Chao Wu, Wen-Yi Shau, Timothy J. Inocencio, Yao-Chun Wen, Hung-I YehBackgroundThe recommended target low-density lipoprotein cholesterol (LDL-C) level for coronary artery disease (CAD) patients has been lowered from 100 to 70 mg/dL in several clinical guidelines for secondary prevention. We aimed to assess whether initiating statin treatment in CAD patients with baseline LDL-C 70&ndash...
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
Publication date: Available online 19 February 2020Source: Pharmacological ResearchAuthor(s): Niki Katsiki, Dimitri P. Mikhailidis, Gani Bajraktari, Andre R. Miserez, Arrigo F.G. Cicero, Eric Bruckert, Maria-Corina Serban, Erkin Mirrakhimov, Fahad Alnouri, Željko Reiner, György Paragh, Amirhossein Sahebkar, Maciej Banach, on behalf of the International Lipid Expert Panel (ILEP)
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
ConclusionThe results suggest that polyphenols present in P. fraternus may be responsible for the anti-diabetic and renoprotective activity in rats. Such protective effects of could be mediated through flavonol-induced anti-oxidant and anti-inflammatory activities in the pancreas and kidneys.Graphical abstract
Source: Journal of Ayurveda and Integrative Medicine - Category: Complementary Medicine Source Type: research
In conclusion, non‐viral gene therapy to rBCECs leads to protein secretion and signifies a method for NPC2 to target cells inside the CNS otherwise inaccessible due to the pres ence of the BBB. However, obtaining high transfection efficiencies is crucial in order to achieve sufficient therapeutic effects.
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research
CONCLUSIONS: Elevated levels of sdLDL-C were associated with a higher prevalence of AIS, especially in non-cardioembolic stroke subtypes. After adjustment for other risk factors, sdLDL-C was found to be an independent risk factor for AIS. Also, sdLDL-C level was strongly associated with AIS severity and poor functional outcomes. Logistic regression models for AIS risk and prognosis prediction were established to help clinicians provide better prevention for high-risk subjects and monitor their prognosis. PMID: 32062644 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
(Oregon State University) Gene-infused nanoparticles used for combating disease work better when they include plant-based relatives of cholesterol because their shape and structure help the genes get where they need to be inside cells.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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