The emergence of preclinical studies on the role of the microbiome in lung development and experimental animal models of bronchopulmonary dysplasia.

The emergence of preclinical studies on the role of the microbiome in lung development and experimental animal models of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2020 Jan 22;: Authors: Casado F, Morty RE PMID: 31967848 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - Category: Cytology Authors: Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Related Links:

(Elsevier) Prematurely born babies often need oxygen therapy to prevent brain damage or death. Unfortunately, excessive oxygen can damage immature lungs and cause severe life-long problems including bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH). A new study in The American Journal of Pathology, published by Elsevier, provides insights into the important role that the hormone adrenomedullin plays in the development, recovery, and prevention of BPD and PH.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Bronchopulmonary dysplasia continues to cause important respiratory morbidity throughout life, and new therapies are needed. The common denominator of all BPD cases is preterm birth, however most preclinical r...
Source: Respiratory Research - Category: Respiratory Medicine Authors: Tags: Research Source Type: research
To determine associations between home oxygen use and 1-year readmissions for preterm infants with bronchopulmonary dysplasia (BPD) discharged from regional neonatal intensive care units.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Original Articles Source Type: research
Bronchopulmonary dysplasia (BPD) –associated pulmonary hypertension (PH) is an infantile lung disease characterized by aberrant angiogenesis and impaired resolution of lung injury. Adrenomedullin (AM) signals through calcitonin receptor–like receptor and receptor activity–modifying protein 2 and modulates lung injury initiati on. However, its role in lung injury resolution and the mechanisms by which it regulates angiogenesis remain unclear. Consequently, we hypothesized that AM resolves hyperoxia-induced BPD and PH via endothelial nitric oxide synthase (NOS3).
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular article Source Type: research
Conditions:   Infant, Premature, Diseases;   Bronchopulmonary Dysplasia;   Respiratory Distress Syndrome Intervention:   Device: Non-invasive forced airway oscillometry Sponsor:   Winston Manimtim Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
PMID: 32066139 [PubMed - as supplied by publisher]
Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research
Abstract BACKGROUND: The addition of budesonide (Bud) 0.25 mg/kg to surfactant decreased the lung and systemic responses to mechanical ventilation in preterm sheep and the rates and severity of bronchopulmonary dysplasia (BPD) in preterm infants. We hypothesized that lower budesonide concentrations in surfactant will decrease injury while decreasing systemic corticosteroid exposure. METHODS: Preterm lambs received either (1) protective tidal volume (VT) ventilation with surfactant from birth or (2) injurious VT ventilation for 15 min and then surfactant treatment. Lambs were further assigned to ...
Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research
This study highlights the potential benefit of using iPSCs to repair damaged lung tissue through possible modulation of the inflammatory response, leading to novel therapies for acute hyperoxia-induced lung injury and the prevention of bronchopulmonary dysplasia. PMID: 32051754 [PubMed]
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Abstract BACKGROUND: To assess the growth outcomes at 18 months corrected age in very low birth weight (VLBW) infants compared to standardized norms, and in VLBW infants with and without bronchopulmonary dysplasia (BPD) or fetal growth restriction (FGR). METHODS: In all, 1149 VLBW infants completed anthropometrics at 18 months corrected age. To derive weight, height, and body mass index (BMI) percentiles and z-scores at 18 months, we used the SAS macro from the Centers for Disease Control and Prevention (CDC). z-scores for a child's sex and age are based on the World Health Organization's growth charts for children
Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research
Conditions:   Infant, Premature, Diseases;   Bronchopulmonary Dysplasia;   Respiratory Distress Syndrome Intervention:   Device: Non-invasive forced airway oscillometry Sponsor:   Winston Manimtim Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Bronchopulmonary Dysplasia | Cytology | Physiology | Study