GSE144073 mRNA seguencing of the ileum tissue from gnotobiotic pigs inoculated with/without Enterobacter cloacae and Human norovirus GII

Contributor : Byung-joo ParkSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaPurpose: We investigated the host immune response and the virus evasion mechanism in gnotobiotic pig infected with HuNoV by mRNA sequencing.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Sus scrofa Source Type: research

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In this study, we investigated the molecular characteristics and spatio-temporal dynamics of GII.P17-GII.17 norovirus in Zhoushan Islands during 2013 –2018. We collected 1849 samples from sporadic acute gastroenteritis patients between January 2013 and August 2018 in Zhoushan Islands, China. Among the 1849 samples, 134 (7.24%) samples were positive for human norovirus (HuNoV). The complete sequence of GII.17 VP1 gene was amplified from 31 HuNoV -positive samples and sequenced. A phylogenetic tree was constructed based on the full-length sequence of the VP1 gene. Phylogenetic analysis revealed that the GII.17 genotype...
Source: Virus Genes - Category: Genetics & Stem Cells Source Type: research
This study aimed to investigate the presence of enterovirus in PLHIV (people living with HIV) and HIV-negative individuals in Ghana. Stool samples from HIV-positive individuals (n = 250) and healthy blood donors (n = 102) attending the Komfo Anokye Teaching Hospital in Kumasi, Ghana, were screened by real-time PCR for enterovirus. Molecular typing of the VP1 region was performed. Enterovirus-positive samples were tested for norovirus, adenovirus, rotavirus, sapovirus, and cosaviruses. Twenty-six out of 250 HIV-positive subjects (10.4%) and 14 out of 102 HIV-negative individuals (13.7%) were detected enterovirus-positive, n...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
(University of East Anglia) The rise of fake news could be making disease outbreaks worse -- according to new research from the University of East Anglia (UEA). Researchers focused on influenza, monkeypox and norovirus across two studies -- but they say their findings could also be useful for dealing with the COVID-19 Coronavirus outbreak.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
CONCLUSION: How feasible it is to achieve these targets within communication networks (online and offline) should be explored. PMID: 32037129 [PubMed - as supplied by publisher]
Source: Revue d Epidemiologie et de Sante Publique - Category: Epidemiology Tags: Rev Epidemiol Sante Publique Source Type: research
In this study, we investigated the effects and mode-of-action of MDA5 on the infection of enteric viruses. We found that MDA5 potently inhibited HEV, HuNV and rotavirus replication in multiple cell models. Overexpression of MDA5 induced transcription of important antiviral ISGs through IFN-like response, without triggering of functional IFN production. Interestingly, MDA5 activates the expression and phosphorylation of STAT1, which is a central component of the JAK-STAT cascade and a hallmark of antiviral IFN response. However, genetic silencing of STAT1 or pharmacological inhibition of the JAK-STAT cascade only partially ...
Source: Antiviral Therapy - Category: Virology Source Type: research
Conclusions: Children with diarrhea regularly carried toxigenic and non-toxigenic strains of C. difficile, demonstrating enhanced microbiotal diversity, and change in milieu, without apparent morbidity. This unexpected finding is contrary to that seen in adults with C. difficile disease.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Pathogenesis and Host Response Source Type: research
Environmental Science&TechnologyDOI: 10.1021/acs.est.9b05747
Source: Environmental Science and Technology - Category: Environmental Health Authors: Source Type: research
In this study, we investigated the effects and mode-of-action of MDA5 on the infection of enteric viruses. We found that MDA5 potently inhibited HEV, HuNV and rotavirus replication in multiple cell models. Overexpression of MDA5 induced transcription of important antiviral ISGs through IFN-like response, without triggering of functional IFN production. Interestingly, MDA5 activates the expression and phosphorylation of STAT1, which is a central component of the JAK-STAT cascade and a hallmark of antiviral IFN response. However, genetic silencing of STAT1 or pharmacological inhibition of the JAK-STAT cascade only partially ...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
The outbreak has prompted an investigation by state health officials.
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
M. Jin et al.
Source: Emerging Infectious Diseases Journal - Category: Infectious Diseases Source Type: research
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