Acute histoplasmosis in travelers: a retrospective study in an Italian referral center for tropical diseases.

Conclusions: Clinical, laboratory and radiological features of histoplasmosis can mimic other conditions, resulting in unnecessary invasive diagnostic procedures. However, a history of travel to endemic areas and of exposure to risk factors (such as visits to caves and presence of bats) should trigger the clinical suspicion of histoplasmosis. Treatment may be indicated in severe or prolonged disease. PMID: 31959091 [PubMed - as supplied by publisher]
Source: Pathogens and Global Health - Category: International Medicine & Public Health Tags: Pathog Glob Health Source Type: research

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Abstract We conducted a systematic literature review to obtain risk population-based fungal disease incidence or prevalence data from China. Data were categorized by risk factors and extrapolated by using most recent demographic figures. A total of 71,316,101 cases (5.0% of the population) were attributed to 12 risk factors and 17 fungal diseases. Excluding recurrent Candida vaginitis (4,057/100,000 women) and onychomycosis (2,600/100,000 persons), aspergillosis (317/100,000 persons) was the most common problem; prevalence exceeded that in most other countries. Cryptococcal meningitis, an opportunistic infection, ...
Source: Emerging Infectious Diseases - Category: Infectious Diseases Authors: Tags: Emerg Infect Dis Source Type: research
Abstract In endemic areas, dimorphic fungal infections due to Histoplasma capsulatum, Blastomyces dermatitidis, and Coccidioides posadasii/immitis account for up to 30% of cases of community-acquired pneumonia. Because respiratory manifestations are often indistinguishable from common bacterial causes of pneumonia, the diagnosis of pulmonary histoplasmosis, blastomycosis, and coccidioidomycosis is often delayed and associated with antibiotics overuse. In addition to being highly endemic to certain regions of North America, dimorphic fungi have global significance due to established areas of endemicity in all six i...
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Semin Respir Crit Care Med Source Type: research
Semin Respir Crit Care Med 2020; 41: 522-537 DOI: 10.1055/s-0040-1702194In endemic areas, dimorphic fungal infections due to Histoplasma capsulatum, Blastomyces dermatitidis, and Coccidioides posadasii/immitis account for up to 30% of cases of community-acquired pneumonia. Because respiratory manifestations are often indistinguishable from common bacterial causes of pneumonia, the diagnosis of pulmonary histoplasmosis, blastomycosis, and coccidioidomycosis is often delayed and associated with antibiotics overuse. In addition to being highly endemic to certain regions of North America, dimorphic fungi have global significan...
Source: Seminars in Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Review Article Source Type: research
AbstractPurpose of ReviewTo describe the different characteristics of mycetoma in the endemic area of Argentina and its etiological agents, using mainly data from Santiago del Estero and Salta provinces. Argentina is not considered an important endemic area, but it possesses a large documented casuistry and many non-published cases of patients.Recent FindingsSantiago del Estero presents the greatest quantity of mycetoma cases of the country, mainly byActinomadura madurae. The First Argentinian Mycetoma Reunion took place in 2016, which was the starting point to train medics and healthcare professionals of the province, whi...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
Clinically significant fungal infections of the upper extremity are uncommon but increasing They are classified based on anatomic location and epidemiology. The anatomic categories that affect the hand include cutaneous, subcutaneous, and deep. Cutaneous infections are caused by organisms that metabolize keratin and can cause serious morbidity but are rarely fatal. Subcutaneous infections are similar to the cutaneous infections and are produced by low virulence organisms. Cutaneous and subcutaneous infections are most common and can be treated by primary care physicians and dermatologists. Deep infections are less common b...
Source: Hand Clinics - Category: Orthopaedics Authors: Source Type: research
Authors: Kelly BT, Pennington KM, Limper AH Abstract Introduction: Fungal infections are increasingly encountered in clinical practice due to more favorable environmental conditions and increasing prevalence of immunocompromised individuals. The diagnostic approach for many fungal pathogens continues to evolve. Herein, we outline available diagnostic tests for the most common fungal infections with a focus on recent advances and future directions.Areas covered: We discuss the diagnostic testing methods for angioinvasive molds (Aspergillus spp. and Mucor spp.), invasive yeast (Candida spp. and Cryptococcus sp.), Pne...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
AbstractPurpose of ReviewFungal infections of the central nervous system (CNS) occur more commonly in immunosuppressed individuals. However, they are being recognized in apparently immune-competent hosts in recent times. Understanding the risk factors, characters of the fungus, and pathogenesis is important.Recent FindingsFungal infections of CNS in apparently immune-competent hosts are described following neurosurgical procedures, head trauma, patients exposed to contaminated devices/drugs, or natural disasters. Disruption of the meninges and blood-brain barrier and direct inoculation of the fungal spores into the subarac...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
Authors: Papachristou SG, Iosifidis E, Sipsas NV, Gamaletsou MN, Walsh TJ, Roilides E Abstract Introduction: Osteoarticular fungal infections (OAFIs) complicate the clinical course of high-risk patients, including immunosuppressed individuals. Their management, however, despite being intricate, is governed by evidence arising from sub-optimal quality research, such as case series. Guidelines are scarce and when present result in recommendations based on low quality evidence. Furthermore, the differences between the management of immunocompromised and immunocompetent patients are not distinct. This is a narrative re...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
Human histoplasmosis is a fungal infection caused by the inhalation of microconidia of the thermally dimorphic fungi Histoplasma capsulatum. Autochthonous cases of histoplasmosis have been diagnosed in almost every country, but it is considered an endemic infection in specific areas of the world. Many of them are popular travel destinations or the source of migratory movements. Thus, the vast majority of the registered cases in non-endemic countries are imported. They correspond to people having been exposed to the fungus in endemic locations as immigrants, expatriates, transient workers or tourists, with reported cases al...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
AbstractPurpose of ReviewCoccidioidomycosis is a systemic fungal infection endemic in Southwestern United States, Northern Mexico, Central and South America. Coccidioidal infection is not well characterized in pediatric population; but due to an increasing incidence in this age group, a special interest had surged to further describe clinical findings, treatment and clinical course of pediatric patients with coccidioidomycosis.Recent FindingsIn the last few years new data about coccidioidomycosis in children and adolescents has been published, including the report of increasing incidence in general population, making a hig...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
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