Acute histoplasmosis in travelers: a retrospective study in an Italian referral center for tropical diseases.

Conclusions: Clinical, laboratory and radiological features of histoplasmosis can mimic other conditions, resulting in unnecessary invasive diagnostic procedures. However, a history of travel to endemic areas and of exposure to risk factors (such as visits to caves and presence of bats) should trigger the clinical suspicion of histoplasmosis. Treatment may be indicated in severe or prolonged disease. PMID: 31959091 [PubMed - as supplied by publisher]
Source: Pathogens and Global Health - Category: International Medicine & Public Health Tags: Pathog Glob Health Source Type: research

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ConclusionsThe clinical manifestations in these Mexican CGD patients were similar to those in patients elsewhere. This cohort is the largest in Latin America. Mycobacterial infections are an important cause of morbidity in Mexico, as in other countries in which tuberculosis is endemic and infants are vaccinated with BCG. X-linked CGD accounted for most of the cases in Mexico, as in other Latin American countries. However, a significant number ofCYBA andNCF2 mutations were identified, expanding the spectrum of known causal mutations.
Source: Journal of Clinical Immunology - Category: Allergy & Immunology Source Type: research
AbstractPurpose of ReviewThis review summarizes the analysis of the internal transcribed spacers (ITS) sequencing ofCoccidioides spp. strains isolated in the endemic region of coccidioidomycosis in Argentina, to be able to associate the presence of a specific fungal genotype with a specific geographical region.Recent FindingsRecent studies have focused on the identification and genetic variability between and intraspecies as a tool to contribute to the coccidioidomycosis epidemiology; these findings may contribute to the specific identification of circulating strains ofCoccidioides spp. in Argentina.SummaryCoccidioides imm...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
Publication date: Available online 19 December 2019Source: Medical Mycology Case ReportsAuthor(s): Akihide Nakamura, Isao Tawara, Kazuko Ino, Takeshi Matsumoto, Akinobu Hayashi, Hiroshi Imai, Yasunori Muraosa, Katsuhiko Kamei, Naoyuki KatayamaAbstractHistoplasmosis, a fungal infection caused by Histoplasma capsulatum, is poor prognosis once it disseminated, especially in immunocompromised patients. A 50-year-old Japanese-Brazilian male with multiple cervical lymphadenopathies was diagnosed as disseminated histoplasmosis and acquired immunodeficiency syndrome (AIDS). Anti-fungal therapy was initiated followed by anti-retrov...
Source: Medical Mycology Case Reports - Category: Biology Source Type: research
Conclusions: PCM occur predominantly in white men, and the main clinical aspect was painful mulberry-like ulcer on the tongue. The recognition of oral lesions is important because sometimes they are the first manifestation of PCM, frequently preceding even pulmonary lesions.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Paracoccidioidomycosis (PCM) is a deep fungal infection caused by Paracoccidioides brasiliensis. PCM is endemic and acquired exclusively in Latin America, with most cases reported in Brazil, Argentina, Colombia, and Venezuela.Objective: To establish a clinical profile of the patients with PCM.Study Design: The authors analyzed retrospectively 94 clinical files of patients with PCM attended at a university stomatology service.Results: Of these patients, 91% were male and 8.5% female, 94.6% were white, and 29.8% were rural workers with mean age of 49.3 years.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
án J Abstract Tumor necrosis factor (TNF) is a proinflammatory cytokine involved in a wide range of important physiologic processes and has a pathologic role in some diseases. TNF antagonists (infliximab, adalimumab, etanercept) are effective in treating inflammatory conditions. Antilymphocyte biological agents (rituximab, alemtuzumab), integrin antagonists (natalizumab, etrolizumab and vedolizumab), interleukin (IL)-17A blockers (secukinumab, ixekizumab) and IL-2 antagonists (daclizumab, basiliximab) are widely used after transplantation and for gastroenterological, rheumatological, dermatological, neurolo...
Source: Revista Iberoamericana de Micologia - Category: Biology Authors: Tags: Rev Iberoam Micol Source Type: research
Publication date: Available online 6 December 2019Source: Wilderness &Environmental MedicineAuthor(s): James H. DiazCryptococcus neoformans, a soil-dwelling fungus found worldwide, can cause cryptococcosis, an opportunistic fungal infection of the lungs and central nervous system. One former member of the C neoformans complex, Cryptococcus gattii, has caused meningitis in immunosuppressed and immunocompetent persons in endemic regions in Africa and Asia. Between 1999 and 2004, C gattii caused outbreaks of human cryptococcosis in unexpected, nonendemic, nontropical regions on Vancouver Island, Canada, and throughout the...
Source: Wilderness and Environmental Medicine - Category: Environmental Health Source Type: research
AbstractPurpose of the ReviewThis review is aimed to overview clinical and epidemiological aspects, as well as the diagnosis and management of four endemic mycosis in children.Recent FindingsThe studies available in the specialized literature concerning endemic mycosis in children are scarce and have great variation due to the characteristic heterogeneity of diseases.SummaryThe clinical image of these diseases shows clear differences as well as their expression in immunocompromised patients. An understanding of the geographic range, typical manifestations, diagnostic methods, and treatment of the endemic mycoses is key in ...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
Purpose of review Invasive fungal infections (IFIs) most often occur secondary to acquired immunodeficiency states such as transplantation, AIDS or immune-modulatory treatment for neoplastic and autoimmune disorders. Apart from these acquired conditions, several primary immunodeficiency disorders (PIDs) can present with IFIs in the absence of iatrogenic immunosuppression. This review highlights recent advances in our understanding of PIDs that cause IFIs, which may help clinicians in the diagnosis and management of such infections. Recent findings A growing number of PIDs that cause varying combinations of invasive in...
Source: Current Opinion in Infectious Diseases - Category: Infectious Diseases Tags: ANTIMICROBIAL AGENTS: BACTERIAL/FUNGAL: Edited by Monica Slavin Source Type: research
DiscussionEven in this previously highly VL endemic area, PKDL is a rare condition. Nevertheless, even a single case can trigger a new VL outbreak. Leprosy is also a rare disease, but current prevalence is over 17 times the elimination threshold proclaimed by WHO. Both diseases require continued surveillance. Active case finding for leprosy can be recommended among household members and close neighbors of leprosy patients but would not be feasible for entire populations. Periodic skin camps may be a feasible and affordable alternative.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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