Synthesis of silver nanoparticles using curcumin-cyclodextrins loaded into bacterial cellulose based hydrogels for wound dressing applications.

Synthesis of silver nanoparticles using curcumin-cyclodextrins loaded into bacterial cellulose based hydrogels for wound dressing applications.
Biomacromolecules. 2020 Jan 22;:
Authors: Gupta A, Briffa SM, Swingler S, Gibson H, Kannappan V, Adamus G, Kowalczuk MM, Martin C, Radecka I
Abstract
Chronic wounds are often recalcitrant to treatment due to high microbial bioburden and the problem of microbial resistance. Silver is a broad spectrum natural antimicrobial agent with wide applications extending to proprietary wound dressings. Recently silver nanoparticles have attracted attention in wound management. In the current study, the green synthesis of nanoparticles was accomplished using a natural reducing agent, curcumin which is a natural polyphenolic compound, well known as a wound healing agent. The hydrophobicity of curcumin was overcome by its microencapsulation in cyclodextrins. This prediction study demonstrates the production, characterisation of silver nanoparticles using aqueous curcumin:hydroxypropyl-β-cyclodextrin complex and loading them into bacterial cellulose hydrogel with moist wound healing properties. These silver nanoparticle-loaded bacterial cellulose hydrogels were characterised for wound management applications. In addition to high cytocompatibility, these novel dressings exhibited antimicrobial activity against three representative wound infecting pathogenic microbes Staphylococcus aureus, Pseudomonas. aerugi...

Source: Biomacromolecules - January 21, 2020 Category: Biochemistry Authors: Gupta A, Briffa SM, Swingler S, Gibson H, Kannappan V, Adamus G, Kowalczuk MM, Martin C, Radecka I Tags: Biomacromolecules Source Type: research