Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases.

Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases. Chem Biol Interact. 2020 Jan 19;:108947 Authors: Tew XN, Xin Lau NJ, Chellappan DK, Madheswaran T, Zeeshan F, Tambuwala MM, Aljabali AA, Balusamy SR, Perumalsamy H, Gupta G, Oliver BG, Hsu A, Wark P, Reddy K, Wadhwa R, Hansbro PM, Dua K Abstract Inflammatory responses play a remarkable role in the mechanisms of acute and chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, pulmonary fibrosis and lung cancer. Currently, there is a resurgence in the use of drugs from natural sources for various ailments as potent therapeutics. Berberine, an alkaloid prominent in the Chinese traditional system of medicine has been reported to exert therapeutic properties in various diseases. Nevertheless, the number of studies focusing on the curative potential of berberine in inflammatory diseases involving the respiratory system is limited. In this review, we have attempted to discuss the reported anti-inflammatory properties of berberine that function through several pathways such as, the NF-κB, ERK1/2 and p38 MAPK pathways which affect several pro-inflammatory cytokines in the pathophysiological processes involved in chronic respiratory diseases. This review would serve to provide valuable information to researchers who work in this field and a new direction in the field of drug discovery with respect to respiratory d...
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Tags: Chem Biol Interact Source Type: research

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Publication date: Available online 20 January 2020Source: Chemico-Biological InteractionsAuthor(s): Xin Nee Tew, Natalie Jia Xin Lau, Dinesh Kumar Chellappan, Thiagarajan Madheswaran, Farrukh Zeeshan, Murtaza M. Tambuwala, Alaa AA. Aljabali, Sri Renukadevi Balusamy, Haribalan Perumalsamy, Gaurav Gupta, Brian G. Oliver, Alan Hsu, Peter Wark, Karosham Reddy, Ridhima Wadhwa, Philip Michael Hansbro, Kamal DuaAbstractInflammatory responses play a remarkable role in the mechanisms of acute and chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, pulmonary fibrosis and lung cancer. Currently,...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: Available online 8 January 2020Source: Redox BiologyAuthor(s): Jennifer L. Larson-Casey, Chao He, A.Brent CarterAbstractMechanisms underlying the pathogenesis of pulmonary fibrosis remain incompletely understood. Emerging evidence suggests changes in mitochondrial quality control are a critical determinant in many lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, pulmonary hypertension, acute lung injury, lung cancer, and in the susceptibility to pulmonary fibrosis. Once thought of as the kidney-bean shaped powerhouses of the cell, mitochondria are now known to form interconne...
Source: Redox Biology - Category: Biology Source Type: research
ConclusionThe use of ICS by the patients with CAP admitted to the hospital is not independently related with any radiological pattern, hospitalization duration and mortality. ICS usage may diminish fever response and may suppress the findings of crackles and/or bronchial sounds. This needs further confirmation.
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
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CONCLUSION: The increase of miR-7 methylation levels experienced by COPD patients occurs mainly at the expense of the emphysema phenotype, which might contribute to explain the higher incidence of lung cancer in these patients. PMID: 31780284 [PubMed - as supplied by publisher]
Source: Archivos de Bronconeumologia - Category: Respiratory Medicine Authors: Tags: Arch Bronconeumol Source Type: research
Conclusion: Frailty is common in CRD patients referred to PR and this data suggests pulmonary rehabilitation is effective in CRD irrespective of frailty status.Reference:1 Mittal J Prim Care Community Health 2016;7(1)10-15
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Physiotherapists Source Type: research
Conclusion: Influenza with CLD is associated with longer length of stay in under 50’s compared to non-CLD. Readmission and mortality were higher in CLD patients.Table 1.AgeNo of patientsPts with CLDsMean Hospital stay (Days)Pts without CLDsMean Hospital Stay(Days)18-30417(17%)11.234(83%)1.231-505818(31%)5.240(69%)2.651-6511143(39%)8.168(61%)7.566-7513956(40%)9.683(60%)11.576-8516352(32%)14111(68%)15.586-9915642(27%)19.5114(73%)20.2
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
Conclusion: The determinants of suitability for HD-ICS prescription in primary care records are inconsistently recorded, difficult to identify and challenging to apply.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: General practice and primary care Source Type: research
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