miR-124/IRE-1 α affects renal ischemia/reperfusion injury by regulating endoplasmic reticulum stress in renal tubular epithelial cells.
In conclusion, our data indicated that miR-124 was a negative regulator of ERS via binding to IRE-1α, ultimately conferring its protective effect on the kidney, which demonstrates the regulatory mechanism of miR-124 in renal I/R injury and provides new ideas and methods for the prevention and treatment of renal I/R injury.
PMID: 31965139 [PubMed - as supplied by publisher]
Source: Acta Biochimica et Biophysica Sinica - Category: Biochemistry Authors: Ding C, Dou M, Wang Y, Li Y, Wang Y, Zheng J, Li X, Xue W, Ding X, Tian P Tags: Acta Biochim Biophys Sin (Shanghai) Source Type: research