Necroptosis and Caspase-2-Mediated Apoptosis of Astrocytes and Neurons, but Not Microglia, of Rat Hippocampus and Parenchyma Caused by Angiostrongylus cantonensis Infection

This study provides the first evidence that neuronal and astrocytic necroptosis and caspase-2-mediated apoptosis are induced by A. cantonensis infection in the parenchymal and hippocampal regions of rats at 21 and 28 dpi but these processes are negligible at 35 dpi. These findings enhance our understanding of the pathogenesis of A. cantonensis infection and provide new insights into therapeutic approaches targeting the occurrence of cell death in astrocytes and neurons in infected patients.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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Authors: Reichrath J, Reichrath S Abstract The evolutionary highly conserved Notch pathway, which first developed during evolution in metazoans and was first discovered in fruit flies (Drosophila melanogaster), governs many core processes including cell fate decisions during embryonic development. A huge mountain of scientific evidence convincingly demonstrates that Notch signaling represents one of the most important pathways that regulate embryogenesis from sponges, roundworms, Drosophila melanogaster, and mice to humans. In this review, we give a brief introduction on how Notch orchestrates the embryonic develop...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
ConclusionThe present study demonstrated that closure of the widely opened frontal sinus using DuraGen inserted between the skull and the pericranium flap is an effective and promising method for the frontal sinus isolation.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
Publication date: Available online 14 February 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Sinan Mermer, Tuncer Turhan, Elif Bolat, Sohret Aydemir, Tansu Yamazhan, Husnu Pullukcu, Bilgin Arda, Hilal Sipahi, Sercan Ulusoy, Oguz Resat SipahiAbstractObjectivesHerein, we aimed to compare the antibacterial activity of ceftaroline and vancomycin in the treatment of MRSA meningitis in experimental rabbit meningitis model.MethodsWe compared the antibacterial activity of ceftaroline with vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis (induced by MRSA strain ATCC 433...
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
AbstractNeisseria gonorrhoeae causes the sexually transmitted infection gonorrhea, whileNeisseria meningitidis is an important cause of bacterial meningitis and sepsis. Complement is a central arm of innate immune defences and plays an important role in combating Neisserial infections. Persons with congenital and acquired defects in complement are at a significantly higher risk for invasive Neisserial infections such as invasive meningococcal disease and disseminated gonococcal infection compared to the general population. Of note,Neisseria gonorrhoeae andNeisseria meningitidis can only infect humans, which in part may be ...
Source: FEBS Letters - Category: Biochemistry Authors: Tags: REVIEW Source Type: research
Craniopharyngiomas are defined by the WHO as “benign” tumours, but their location and surgical treatment may be associated with major complications, one being chemical meningitis. Although rare, especially in ...
Source: BMC Neurology - Category: Neurology Authors: Tags: Case report Source Type: research
Abstract Primary pulmonary coccidioidomycosis (valley fever) is caused by inhaling airborne spores of the fungus Coccidioides immitis or Coccidioides posadasii. Residing in or traveling to areas endemic for Coccidioides is required for the diagnosis; no person-to-person or zoonotic contagion occurs. The incidence of coccidioidomycosis is increasing in endemic areas, and it has been identified as the cause of as many as 17% to 29% of all cases of community-acquired pneumonia in some regions. Obtaining a travel history is recommended when evaluating patients with community-acquired pneumonia. Diagnosis usually relie...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
Authors: Aladağ Çiftdemir N, Duran R, Vatansever Özbek Ü, Hançerli Törün S, Acunaş B, Ünal Şahin N Abstract Meningococcal infections are important health problems causing high morbidity and mortality. Neisseria meningitidis have 13 serogroups. A, B, C, Y and W135 are the most common causes of invasive disease among those serogroups. The distribution of the serogroups differs according to the geographical regions and the age groups. In this case report, two cases of meningococcemia infected with serogroup C and Y of N.meningitidis rarely seen in our country were presented. F...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
In this study, when the distribution of virulence genes were compAred with the isolates that have weak, medium and strong biofilm, all of the studied genes were found to be more abundant in isolates with strong and medium positive biofilm production. This has shown that excluding fimH gene, csgA, csuE and ompA genes have contributed to the biofilm formation in invasive A.baumannii isolates, respectively. PMID: 32050877 [PubMed - in process]
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
ConclusionThe increase in the prevalence of CNSP using meningitis breakpoint was observed. For treating pneumococcal meningitis, empirical monotherapy with ceftriaxone might not be adequate. Imipenem and meropenem might not be a good choice for empirical treatment of adult IPDs. Antibiotic resistance of pneumococcus to ceftriaxone, cefepime, imipenem and meropenem were associated with 13-velent pneumococcal conjugate vaccine serotypes.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
AbstractNeisseria gonorrhoeae causes the sexually transmitted infection gonorrhea, whileNeisseria meningitidis is an important cause of bacterial meningitis and sepsis. Complement is a central arm of innate immune defences and plays an important role in combating Neisserial infections. Persons with congenital and acquired defects in complement are at a significantly higher risk for invasive Neisserial infections such as invasive meningococcal disease and disseminated gonococcal infection compared to the general population. Of note,Neisseria gonorrhoeae andNeisseria meningitidis can only infect humans, which in part may be ...
Source: FEBS Letters - Category: Biochemistry Authors: Tags: REVIEW Source Type: research
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