Africa: As J & J Releases Earnings, MSF Protests Price of Lifesaving TB Drug in Front of New York Stock Exchange

[MSF] New York -Doctors Without Borders/M édecins Sans Frontières (MSF) protested in front of the New York Stock Exchange in New York today, demanding the pharmaceutical corporation Johnson&Johnson (J&J) make the tuberculosis (TB) drug bedaquiline available for all people with drug-resistant TB (DR-TB) for no more than a dollar a day. The price of this crucial drug must be lowered to reflect the joint contributions made to its research and development by taxpayers and the global scientific and TB co
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news

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This report describes the methodology adopted and followed through the consensus process, which help elucidate the guidelines for initiating ATT in patients with choroidal TB. PMID: 32250731 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Universal approaches to the prevention and treatment of human diseases fail to take into account profound immune diversity resulting from genetic variations across populations. Personalized or precision medicine takes into account individual lifestyle, environment, and biology (genetics and immune status) and is being adopted in several disease intervention strategies such as cancer and heart disease. However, its application in infectious diseases, particularly global diseases such as tuberculosis (TB), is far more complex and in a state of infancy. Here, we discuss the impact of human genetic variations on immune respons...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
Zororo Makamba wasn’t supposed to die of the novel coronavirus. Not just because of his age, which at 30 placed him well out of the at-risk category for COVID-19 complications, but because of who he was. A well-known, pro-government media personality in Zimbabwe, and the son of a prominent business mogul, Makamba had the wealth and the connections that should have guaranteed him the best care possible. Instead, on March 23, Zimbabwe’s first confirmed case of the coronavirus died alone in a quarantined hospital, three days after his diagnosis. Hospital staff, lacking protective equipment, were afraid to come nea...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
This report highlights some of the knowledge shared at the SPSASV.
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - Category: Tropical Medicine Source Type: research
AbstractBuruli ulcer, the third most common mycobacterial disease worldwide, is caused byMycobacterium ulcerans and characterized by devastating necrotizing skin lesions. Susceptibility to Buruli ulcer is thought to depend on host genetics, but very few genetic studies have been performed. The identification of a microdeletion on chromosome 8 in a familial form of severe Buruli ulcer suggested a monogenic basis of susceptibility. The role of common host genetic variants in Buruli ulcer development has been investigated in only three candidate-gene studies targeting genes involved in mycobacterial diseases. A recent genome-...
Source: Human Genetics - Category: Genetics & Stem Cells Source Type: research
Molecules, Vol. 25, Pages 1684: Determination of d-Cycloserine Impurities in Pharmaceutical Dosage Forms: Comparison of the International Pharmacopoeia HPLC–UV Method and the DOSY NMR Method Molecules doi: 10.3390/molecules25071684 Authors: Damjan Makuc Živa Švab Katerina Naumoska Janez Plavec Zdenko Časar d-cycloserine is a broad-spectrum antibiotic that is currently being used as a secondary choice in the treatment of tuberculosis. In recent years, it has become more popular, due to its effect on the nervous system. In this current study, we provide evidence that The International Pharmacop...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
The Korea Centers for Disease Control&Prevention has implemented a review process for the approval of new drugs used to treat patients with multidrug-resistant tuberculosis (MDR-TB) since September 2016. Therefore, this study aimed to evaluate the efficacy and safety of these new drugs bedaquiline (Bdq) and delamanid (Dlm).
Source: Respiratory Medicine - Category: Respiratory Medicine Authors: Source Type: research
Publication date: Available online 5 April 2020Source: International Journal of Pediatrics and Adolescent MedicineAuthor(s): Saleh Alfawaz, Nadia Alattas, Moza Alhammadi, Saadia Waqar, Sulaiman Al Alola
Source: International Journal of Pediatrics and Adolescent Medicine - Category: Pediatrics Source Type: research
Contributors : Md A Rahman ; Bridgette M Cumming ; Kelvin Addicot ; Hayden Pacl ; Shannon Russell ; Kievershen Nargan ; Threnesan Naidoo ; Pratistadevi K Ramdial ; John H Adamson ; Rui Wang ; Adrie J SteynSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe ubiquitous gasotransmitter hydrogen sulfide (H2S) has been recognised to play a crucial role in human health. However, a role for host H2S in pathogenesis has not yet been demonstrated. Using cystathionine -lyase (CSE) deficient mice, we demonstrated an unexpected role of H2S in Mtb pathogenesis. We showed that Mtb-infected CSE-/...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
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