Tanzania: Traditional Healers Cited As Big Spoilers
[Daily News] HEALTH practitioners in the country have accused traditional medicine men and women of depriving patients suffering from life-threatening illnesses quality palliative care.
Authors: Haber PK, Sia D Abstract Biliary tract cancers (BTC), which include cholangiocarcinoma (both intra- and extrahepatic) and gallbladder, represent a heterogeneous group of malignancies with relatively low-incidence and poor prognosis. Therapeutic options for BTC patients at advanced stage are severely limited and palliative chemotherapy remains the maintreatment option. In the past decade, genome profiling via next-generation sequencing of large international cohorts has paved the way for precision oncology in BTC, identifying unique molecular subtypes, recurrent mutations, and genomic rearrangements. Target...
ConclusionRecurrent FGFR2 amplification was observed in roughly 4.0% of GC patients. High FGFR2 amplification was significantly associated with poor progression free survival and overall survival in GC patients. Clinical studies of FGFR2-directed therapies are warranted and should consider stratification by FGFR2 CNA.
Transcutaneous electrical nerve stimulation (TENS) is primarily used for pain, but might be useful for various other physical symptoms, including nausea, fatigue, dyspnea, and constipation. However, few studies have used TENS for treating the physical symptoms of patients with advanced cancer. In this crossover trial, we assess the effects of TENS on pain and other physical symptoms in 20 in-patients with advanced cancer receiving palliative care. For 5-day phases between wash out periods of 5 days, patients received TENS or non-TENS. TENS was delivered at four points: the center of the back for mainly nausea and dyspnea, ...
ConclusionThis technique is reliable and reproducible, giving good functional results and avoiding the radial deviation of the wrist in extension observed with traditional techniques.Level of evidenceIV.
Malignant pleural mesothelioma (MPM) is a rare, aggressive tumor originating from mesothelial cells. It is associated with exposure to asbestos, mainly occupational, rarely environmental or domestic. Diagnosis is usually made at an advanced stage because symptoms are non-specific and late. The management of this tumor is challenging and outcome is poor. Therapeutic strategies are mainly based on surgery with curative intent or palliative cytotoxic chemotherapy. Few patients are candidates for surgery which must necessarily take into account numerous factors (i.e.
ConclusionConcurrent radio- and/or chemotherapy in combination with surgery seems to result in improved survival in stage IVA/B ATC, whereas this is not the case in patients with stage IVC tumors. Novel treatment regimens are urgently needed to improve the dismal prognosis of ATC.
Deborah Balmer, Rosemary Frey, Merryn Gott, Jackie Robinson, Michal Boyd
In conclusion, patients with advanced melanoma consider efficacy of treatment options most important, followed by safety, but preferences vary with individual and disease-related characteristics. PMID: 32057087 [PubMed - as supplied by publisher]
AbstractObjectivesAcute pancreatitis (AP) is an inimical disorder associated with overall mortality rates between 10 ‐15%. It is a disorder of the exocrine pancreas which is characterized by local and systemic inflammatory responses primarily driven by oxidative stress and death of pancreatic acinar cells. The severity of AP ranges from mild pancreatic edema with complete recuperative possibilities to serious sy stemic inflammatory response resulting in peripancreatic/pancreatic necrosis, multiple organ failure, and death.Key findingsWe have retrieved the potential alternative approaches that are developed lately for eff...
Publication date: Available online 12 February 2020Source: Canadian Journal of CardiologyAuthor(s): Lampson Fan, Andrew J. Lucking, Andrew Kelion, Nikant Sabharwal, Jeremy P. LangrishSummaryThis imaging report illustrates a rare and life-threatening extrinsic compression of left main stem by an aortic pseudo-aneurysm as a late complication of aortic valve replacement. Surgery was traditionally the only option but this elderly lady was deemed to be at unacceptable risk. Rescue percutaneous coronary intervention was performed successfully demonstrating the feasibility of palliative PCI in this type of cases.