Pulmonary infection due to Acrophialophora fusispora in a patient with underlying mixed connective tissue disease and chronic pulmonary aspergillosis: a case report and review of literature

Publication date: Available online 22 January 2020Source: Journal de Mycologie MédicaleAuthor(s): Arghadip Samaddar, Anuradha Sharma, Twishi ShrimaliAbstractAcrophialophora fusispora is a soil-borne fungus rarely implicated in human infections. Here, we report a case of pulmonary infection due to A. fusispora in a 59-year-old male who presented with productive cough and gradually progressive dyspnoea for 20 days. He had a past history of pulmonary tuberculosis and was a known case of chronic obstructive pulmonary disease for past five years. He was diagnosed with mixed connective tissue disease and had been receiving oral azathioprine and prednisolone for three months. CT scan of chest revealed an aspergilloma and serum Aspergillus fumigatus-specific IgG levels were raised, suggestive of chronic pulmonary aspergillosis. He was also tested positive for influenza A (H1N1) and received treatment with oral oseltamivir without any clinical benefit. Culture of sputum and bronchoalveolar lavage fluid showed growth of a fungus which was identified as Acrophialophora fusispora based on characteristic microscopic morphology and internal transcribed spacer sequencing of the ribosomal DNA. Antifungal susceptibility testing for six antifungal drugs showed itraconazole to have the most potent in vitro activity (MIC= 0.25 μg/mL) against A. fusispora in comparison to the other drugs tested. Treatment with itraconazole capsule 200 mg twice daily was initiated and favourabl...
Source: Journal of Medical Mycology - Category: Biology Source Type: research

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Authors: Hosokawa T, Suzuki S, Tanami Y, Sato Y, Ko Y, Nomura K, Oguma E, Yamada Y Abstract In contrast to computed tomography, ultrasound can be performed without radiation exposure, repeatedly performed by the patients' bedside. Hence, in this case series, we describe the evaluation of complications including hematoma, superficialsurgical site infection, mediastinitis, and pseudoaneurysm associated mediastinitis using ultrasound in pediatric patients after cardiovascular surgery. To our knowledge, no previous reports have evaluated such complications using ultrasound. Ultrasound may be useful for the early diagno...
Source: Medical Ultrasonography - Category: Radiology Tags: Med Ultrason Source Type: research
Authors: Morisaki T, Fukuhara T, Matsuda E, Moritani S, Miyake N, Koyama S, Fujiwara K, Takeuchi H Abstract Lymphadenopathy is frequently observed in immunoglobulin G4 (IgG4)-related disease in some cases, and such cases are known as IgG4-related lymphadenopathy. The ultrasonography findings associated with IgG4-related lymphadenopathy have not been described in previous reports. Herein, we describe ultrasonography findings in two cases of IgG4-related lymphadenopathy in conjunction with histopathological findings. Combined ultrasound scanning with Doppler examination accurately represented the specific histopathol...
Source: Medical Ultrasonography - Category: Radiology Tags: Med Ultrason Source Type: research
Authors: Gavrila IL, Badea RI, Jude C, Socaciu MA, Comsa M, Badea AF Abstract Abdominal ultrasound (US) performed as a "primary imaging procedure" is an important diagnostic tool in gastroenterol-ogy. Expanding the routine investigation to the lower thoracic region might sometimes accelerate the diagnosis in inconclusive manifestations such as pulmonary pathology.US is a valuable tool in evaluating patients with breathing difficulties, chest pain, hypoxia, or chest trauma. This paper presents the particular situation of a patient hospitalized in the gastroenterology depart-ment, where the US identified si...
Source: Medical Ultrasonography - Category: Radiology Tags: Med Ultrason Source Type: research
Authors: Maconi G, Sousa M Abstract Gastrointestinal ultrasound (GIUS) has been increasingly used for the management of gastrointestinal disorders due to its potentialities as a cheap, widely available and safe examination with comparable accuracy to other techniques such as Computed Tomography or Magnetic Resonance Imaging. However, some limitations have been stated to justify its underuse such as its dependency on the operator, small field of view and penetration and need of expertise. However, most of these limitations are inherent to any technique. The main problems with GIUS are lack of standardized definition...
Source: Medical Ultrasonography - Category: Radiology Tags: Med Ultrason Source Type: research
Authors: Roman A, Palego F, Achimas-Cadariu P, Vlad C, Andries A, Tomuleasa CI, Gata VA, Pintican R, Rada MP, Feier D Abstract AimsThe present study aims to investigate the pain, anxiety and other factors that are associated with percutaneous computed tomography (CT)- and ultrasound (US)-guided biopsies of tumors.Material and MethodsThe study prospectively included 60 consecutive patients, of which 24 underwent CT-guided biopsies and 36 US-guided biopsies. The location of targeted tumors was within the thorax, abdomen, pelvis, and limbs. A questionnaire containing numerical rate scales (0-10) regarding procedural a...
Source: Medical Ultrasonography - Category: Radiology Tags: Med Ultrason Source Type: research
CONCLUSIONS: In cases of BCCs with thickness of ≤1 mm, there was a high correlation (r=0.870) of the tumor spread depth between micromorphological measurements and the results obtained using a 75 MHz transducer and in cases of BCCs with thickness of>1 mm, a very high correlation (r=0.951) of the tumor spread depth was observed between histomorphometry and30 MHz transducer measurements. PMID: 32096785 [PubMed - as supplied by publisher]
Source: Medical Ultrasonography - Category: Radiology Tags: Med Ultrason Source Type: research
CONCLUSIONS: EUS guided fine needle aspiration/biopsy of focal liver lesions is safe, provides a very high diagnostic accuracy and should not be considered only as a rescue method after failure of percutaneous guided biopsies. PMID: 32096783 [PubMed - as supplied by publisher]
Source: Medical Ultrasonography - Category: Radiology Tags: Med Ultrason Source Type: research
Publication date: 25 February 2020Source: Cell Reports, Volume 30, Issue 8Author(s): Marco Brondi, Monica Moroni, Dania Vecchia, Manuel Molano-Mazón, Stefano Panzeri, Tommaso Fellin
Source: Cell Reports - Category: Cytology Source Type: research
Authors: PMID: 32090629 [PubMed - as supplied by publisher]
Source: Scandinavian Cardiovascular Journal - Category: Cardiology Tags: Scand Cardiovasc J Source Type: research
Publication date: Available online 25 February 2020Source: Food ControlAuthor(s): Son Anh Vo, Joel Scanlan, Paul Turner
Source: Food Control - Category: Food Science Source Type: research
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