Cyclam-based antibacterial molecules eradicate Gram-negative superbugs with potent efficacy against human corneal infection

Chem. Commun., 2020, Advance Article DOI: 10.1039/C9CC06967D, CommunicationMohini Mohan Konai, Iqbal Pakrudheen, Swagatam Barman, Natalia Sharma, Khatija Tabbasum, Prashant Garg, Jayanta Haldar Cyclam-based antibacterial molecules (CAMs) that display potent activity against both the planktonic and stationary phase of multidrug-resistant Gram-negative bacteria were rationally designed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research

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Publication date: Available online 22 February 2020Source: Journal of Hospital InfectionAuthor(s): Sarah Jolivet, Isabelle Lolom, Sébastien Bailly, Lila Bouadma, Brice Lortat-Jacob, Philippe Montravers, Laurence Armand-Lefevre, Jean-François Timsit, Jean-Christophe LucetSummaryBackgroundColonisation pressure is a risk factor for intensive care unit (ICU)-acquired multidrug-resistant organisms (MDROs).AimTo measure the long-term respective impact of colonisation pressure on ICU-acquired extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) and meticillin resistant Staphylococcus aureus (MRS...
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
Outer membrane proteins (OMPs) of gram-negative bacteria play an important role in mediating antibacterial resistance, bacterial virulence and thus affect pathogenic ability of the bacteria. Over the years, prevalence of environmental antibiotic resistant organisms, their transmission to clinics and ability to transfer resistance genes, have been studied extensively. Nevertheless, how successful environmental bacteria can be in establishing as pathogenic bacteria under clinical setting, is less addressed. In the present study, we utilized an integrated approach of investigating the antibiotic resistance profile, presence o...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Sanna Sillankorva The treatment and management of chronic wounds presents a massive financial burden for global health care systems, with significant and disturbing consequences for the patients affected. These wounds remain challenging to treat, reduce the patients’ life quality, and are responsible for a high percentage of limb amputations and many premature deaths. The presence of bacterial biofilms hampers chronic wound therapy due to the high tolerance of biofilm cells to many first- and second-line antibiotics. Due to the appearance of antibiotic-resistant and multidrug-resistant pathogens in these t...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
CONCLUSIONS: Tazobactam can have impact on resistance to aminoglycoside by inhibiting efflux pump. Thus, the combination of tazobactam with amikacin can be used as an alternative treatment approach in multidrug resistant A. baumannii infections. PMID: 32077820 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Biotechnology - Category: Biotechnology Authors: Tags: Curr Pharm Biotechnol Source Type: research
CONCLUSIONS: Broad-spectrum antibiotics were common in patients with haematological malignancies in Japan; however, antibiotic-resistant bacteria including carbapenem-resistant or multidrug-resistant bacteria were infrequent. Our results provide nationwide, cross-sectional insight into the use of antimicrobial agents, prevalence of bacteria, and antibiotic resistance, demonstrating differences in antimicrobial utilization among different haematological diseases. PMID: 32066448 [PubMed - in process]
Source: Clinical Lymphoma and Myeloma - Category: Cancer & Oncology Authors: Tags: Ann Clin Microbiol Antimicrob Source Type: research
In conclusion, this study shows a high prevalence of ESBL- and carbapenemase-producing bacteria in hospital sewage and receiving rivers in China. These findings have serious implications for human health, and also suggest the need for more efforts to control the dissemination of resistant bacteria from hospital sewage into the environment.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
ConclusionThis review shows that there is increasing prevalence of β-lactamase producing P. aeruginosa in some countries in the Arab region. This is a major cause of concern as this implies that more and more instances of multidrug resistance are emerging in this area. This leads to an overall negative impact on the health concerns and amounts to increasing difficulty in combating disease. It is recommended that awareness about antibiotic use and abuse be made a priority and measures of curbing unchecked use of prescription antibiotics be put into place. Effective screening methods to detect cases of resistance at the...
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
This study suggests that exposure of colistin may reduce the susceptibility of vancomycin in certain MRSA strains. Combination therapy with vancomycin and colistin for multidrug-resistant pathogens might result in treatment failure for concurrent MRSA infection. PMID: 32041713 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Xiong Deng Lin New strategies against antibiotic-resistant bacterial pathogens are urgently needed but are not within reach. Here, we present in vitro and in vivo antimicrobial activity of TSPphg, a novel phage lysin identified from extremophilic Thermus phage TSP4 by sequencing its whole genome. By breaking down the bacterial cells, TSPphg is able to cause bacteria destruction and has shown bactericidal activity against both Gram-negative and Gram-positive pathogenic bacteria, especially antibiotic-resistant strains of Klebsiella pneumoniae, in which the complete elimination and highest reduction in bacteria...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
In conclusion, wastewater effluents from the investigated poultry slaughterhouses exhibited clinically relevant bacteria (E. coli, MRSA, K. pneumoniae, species of the ACB-and E. cloacae-complexes) that contribute to the dissemination of clinically relevant resistances (i.e. bla CTX-M/SHV, mcr-1) in the environment.Importance Bacteria from livestock may be opportunistic pathogens and carriers of clinically relevant resistance genes, as many antimicrobials are used both in veterinary and human medicine. They may be released into the environment from wastewater treatment plants (WWTPs) that are influenced by wastewater from s...
Source: Applied and Environmental Microbiology - Category: Microbiology Authors: Tags: Appl Environ Microbiol Source Type: research
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