Seizure in venlafaxine overdose: a 10-year retrospective review of the California poison control system

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Source: Clinical Toxicology - Category: Toxicology Authors: Source Type: research

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Conclusions: Comorbidities such as chronic hypertension and kidney failure were less frequent than in patients with other PRES etiologies. Imaging analysis did not highlight a specific pattern for poisoning-induced PRES. Although less described, PRES in the context of poisoning, which shares most of the clinical and radiological characteristics of other etiologies, is not to be ignored.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
 Many studies have focused on the relationship between naloxone and seizurein tramadol poisoning but the results are in conflict. We performed a meta ‑analysis study to see whether naloxone prevents or increase the risk of seizure in tramadol poisoning.Bibliographic literature searches were conducted in the ISI Web of Science, Excerpta Medica Database (EMBASE), PubMed, and Cochrane from January 1990 to December 2017 for relevant articles. Pooled data were analyzed by calculating odds ratios (ORs) with 95% confidence intervals (CIs). The outcome includes seizure. To investigate the publication bias, Begg ’s and...
Source: International Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Drug- and alcohol-poisoning deaths remain current public health problems. Studies to date have typically focused on individual-level predictors of drug overdose deaths, and there remains a limited understanding of the spatiotemporal patterns and predictors...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Paracetamol overdose is common. If left untreated, liver and/or renal failure can develop. Administration of the antidote, acetylcysteine, within 8 –10 hours of overdose minimizes or prevents liver damage. After overdose, the tests used to identify that patients are at risk of liver injury are well established but have limitations. Once liver injury has occurred, important prognostic factors are the presence of hepatic encephalopathy, the int ernational normalized ratio, acid–base status and renal function.
Source: Medicine - Category: Internal Medicine Authors: Tags: Poisonous substances Source Type: research
Tricyclic antidepressants, citalopram, venlafaxine and monoamine oxidase inhibitors are the most toxic antidepressants in overdose. Features include hypotension and arrhythmias that are best managed by aggressive correction of metabolic acidosis with sodium bicarbonate. Antipsychotic drugs differ in their chemical structure and specificity at dopamine receptors. Overdose produces a range of adverse effects including sedation and acute extrapyramidal reactions. Cardiovascular effects including hypotension, prolongation of the QT interval and, potentially, arrhythmias including torsade de pointes are also seen.
Source: Medicine - Category: Internal Medicine Authors: Tags: Poisonous substances Source Type: research
Self-poisoning accounts for a significant number of attendances to acute services. It can occur at any age. The reasons that lead someone to self-poison are variable and individual. It is often a manifestation of distress. Women are more likely to present, or die, after overdose than men, although men are more likely to die by suicide overall. Self-harm, including self-poisoning, is a strong risk factor and antecedent to suicide. Psychosocial assessment offers an important opportunity to intervene.
Source: Medicine - Category: Internal Medicine Authors: Tags: General aspects of poisoning Source Type: research
Alcohol poisoning is a serious medical emergency due to the overconsumption of alcohol that can result in death. Overconsumption of alcohol affects many systems in the body. The liver, which works to eliminate toxins from the body, is not able to keep up with the high amount being ingested. In turn, the central nervous system becomes so depressed to the point that it cannot perform its normal, essential functions such as beating the heart and breathing. There are many factors that can determine whether or not an individual could suffer from alcohol poisoning, such as: Rate of alcohol consumption Tolerance and dependency ...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Alcohol Alcohol Rehab Information Alcoholism Detox Resources for Alcohol and Drugs/Opiates alcohol abuse alcohol detox alcohol treatment alcohol treatment center alcohol treatment facility Source Type: blogs
Contributors : Julian Krauskopf ; Jos Kleinjans ; Jiri AubrechtSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe study comprises of 24 samples that have been taken over a time course during a lethal APAP overdose
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Today (Dec. 30), a team of researchers from the University of California, San Francisco and the Children’s National Hospital in Washington, D.C., published the results of an investigation into whether or not pharmacy workers could provide accurate information on the disposal of two classes of drugs: opioids and antibiotics. The results are frightening: The researchers enlisted volunteers to place calls to nearly 900 pharmacies in California, posing as parents with leftover antibiotics and opioids from a “child’s” recent surgery. They asked the pharmacy employees on the line—either pharmacists...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized data visualization embargoed study Pharmaceuticals Source Type: news
Conclusion: Comparisons of postmortem concentrations of specific drugs indicated that patients treated with methadone, buprenorphine, and implant naltrexone had comparable susceptibilities to lethal co-intoxication and that similar drug mixtures contributed to death. PMID: 31860367 [PubMed - as supplied by publisher]
Source: The American Journal of Drug and Alcohol Abuse - Category: Addiction Authors: Tags: Am J Drug Alcohol Abuse Source Type: research
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