Vaccination of Infants with Meningococcal Group B Vaccine (4CMenB) in England
New England Journal of Medicine,Volume 382, Issue 4, Page 309-317, January 2020.
ConclusionThe increase in the prevalence of CNSP using meningitis breakpoint was observed. For treating pneumococcal meningitis, empirical monotherapy with ceftriaxone might not be adequate. Imipenem and meropenem might not be a good choice for empirical treatment of adult IPDs. Antibiotic resistance of pneumococcus to ceftriaxone, cefepime, imipenem and meropenem were associated with 13-velent pneumococcal conjugate vaccine serotypes.
This study provides safety information about inadvertent MenACWY-CRM vaccination during pregnancy. METHODS: The evaluated population consisted of pregnant female members of Kaiser Permanente Southern California who inadvertently received MenACWY-CRM at 11-21 years of age during 09/30/2011-06/30/2013 within 28 days prior to conception or during pregnancy. Chart abstraction was conducted to identify pregnancy and birth outcomes, including spontaneous and induced abortions, preterm births, low weight births, and major congenital malformations (MCMs). RESULTS: There were 92 women who received MenACWY-CRM du...
CONCLUSIONS: We detected a small risk of incidental pneumonia associated with varicella vaccine in the 6th week after immunization. There was no increase in the risk of other pre-specified adverse events. PMID: 32046891 [PubMed - as supplied by publisher]
FRIDAY, Feb. 7, 2020 -- The hexavalent combined diphtheria and tetanus toxoids and acellular pertussis (DTaP) adsorbed, inactivated poliovirus (IPV), Haemophilus influenza type b (Hib) conjugate (meningococcal protein conjugate), and hepatitis B...
(Wolters Kluwer Health) Pneumococcal conjugate vaccines (PCVs) have been highly effective in reducing pneumonia and other invasive infections caused by Streptococcus pneumoniae bacteria. But rates of meningitis have shown little change, as pneumococcal strains not targeted by PCVs emerge as more important causes of meningitis, reports a paper in The Pediatric Infectious Disease Journal, the official journal of The European Society for Paediatric Infectious Diseases. The journal is published in the Lippincott portfolio by Wolters Kluwer.
This report summarizes the indications for DTaP-IPV-Hib-HepB and provides guidance for its use. PMID: 32027629 [PubMed - indexed for MEDLINE]
In this study, dOMV vaccines deficient in major OMPs, including PorA, PorB, and RmpM were isolated and used to immunize rabbits and mice. Serum samples were obtained from each animal and tested for antibody responses against five MenB strains. Immunization with wild type dOMVs elicited antibodies to major antigens including PorA, PorB, RmpM, and lipooligosaccharide (LOS), and demonstrated limited bactericidal activity against heterologous strains. In contrast, OMP-deficient dOMV vaccines elicited broadly cross-reactive bactericidal antibodies, with PorA/PorB-dual deficient dOMVs inducing antibodies exhibiting the greatest ...
J. M. Langley et al.
(Meningitis Research Foundation) Research from Bristol University on parents' peace of mind and vaccinations gives us insight that beliefs about vaccines can change, and that peace of mind varies according to different factors. The MenB vaccine, although considered 'new' provided increased reassurance because of the perceived disease severity. Meningitis Research Foundation says parents' peace of mind is currently being ignored when health bodies weigh up vaccine benefits to make decisions whether to introduce vaccines or expand their coverage.