Crucial role of the terminal complement complex in chondrocyte death and hypertrophy after cartilage trauma

Innate immune response and particularly terminal complement complex (TCC) deposition are thought to be involved in the pathogenesis of posttraumatic osteoarthritis. However, the possible role of TCC in regulated cell death as well as chondrocyte hypertrophy and senescence has not been unraveled so far and was first addressed using an ex vivo human cartilage trauma-model.
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Source Type: research