Crossed-Probes Cryoablation for the Treatment of a Sclerotic Vertebral Metastasis Abutting the Spinal Canal

A 44-year-old woman presented with lumbar pain (visual analog scale [VAS]  = 9) secondary to adrenocortical carcinoma sclerotic L4-vertebral metastasis. The positron emission tomography-computed tomography hypermetabolic lesion (Fig 1a,d) was unresponsive to radiotherapy or chemotherapy. She refused surgery. Following general anesthesia and aseptic preparation, 2 power d rill-mounted (Aesculap, Center Valley, Pennsylvania) k-wires were inserted in each vertebral pedicle with lateromedial opposite directions, resulting in crossed wires.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Extreme IR Source Type: research

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AbstractBackgroundPrevious studies have identified that patients withEGFR mutations tend to have better responses to targeted therapy, as well as chemotherapy; however, the effect of genetic alterations in terms of radiotherapy (RT) ‐related outcomes has not been fully assessed. We studied the impact of common non‐small cell lung cancer (NSCLC) genetic alterations (EGFR,ALK andKRAS) in relation to objective response rate (ORR) to RT in patients with brain metastases.MethodsFrom 2009 –2015, 153 patients with an available genotyping status were treated with whole‐brain irradiation (WBI) before receiving systemic ...
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Date: Friday, 02 28, 2020; Speaker: Jonathan Wasserman, Staff Physician, SickKids; BG 10-CRC; FAES 1&2
Source: NIH Calendar of Events - Category: American Health Source Type: events
In this study, we collected raw water from different elements of a local full-scale plant to investigate the fouling characteristics along a two-stage-module NF process. The fouled membranes at different flux decline ratios were autopsied according to scanning electron microscope (SEM), atomic force microscope (AFM), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectrometer (XPS), adenosine triphosphate (ATP), contact angle and zeta potential measurements to track the dynamic evolution of organic, inorganic and biological fouling. Statistical approaches, including principal component analysis (PCA), ...
Source: Journal of Membrane Science - Category: Materials Science Source Type: research
L-GILZ binds and inhibits nuclear factor κB nuclear translocation in undifferentiated thyroid cancer cells. J Chemother. 2020 Feb 18;:1-5 Authors: Marchetti MC, Cannarile L, Ronchetti S, Delfino DV, Riccardi C, Ayroldi E Abstract Proto-oncogene mutations and abnormal activation of mitogen-activated protein kinase (MAPK) signalling are recurrently found in thyroid cancers. Some thyroid neoplasms respond to drugs that inhibit MAPK pathway activation. Previously, we showed that pharmacological inhibition of MAPK in thyroid cancer cells inhibits cell proliferation and upregulates L-GILZ (long glucoco...
Source: Journal of Chemotherapy - Category: Cancer & Oncology Tags: J Chemother Source Type: research
Authors: Maruta M, Miyoshi T, Matsuo N, Yamashina T, Irie K, Tsuruta M, Tsukada H, Tsuruyama M, Nagano M, Hiraki Y Abstract We administered FOLFOX (oxaliplatin (L-OHP) plus infusional 5-fluorouracil (5-FU) and leucovorin) to an hemodialysis (HD) patient with advanced gastric cancer (AGC), and investigated pharmacokinetics (PKs) and dialyzability of L-OHP. The patient was a 54-year-old Japanese man with a diagnosis of inoperable AGC. FOLFOX was instituted 3 h prior to the start of a 4 h HD period with the L-OHP and 5-FU doses reduced by 50% for the first cycle, and 30% reduced dose was administered for...
Source: Journal of Chemotherapy - Category: Cancer & Oncology Tags: J Chemother Source Type: research
Publication date: Available online 19 February 2020Source: Prostaglandins &Other Lipid MediatorsAuthor(s): Anne Barden, Michael Phillips, Emilie Mas, Lisa M. Hill, Ian Mowat, P.S. Loh, Tomas Corcoran, Trevor A. Mori
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research
This study was aimed to estimate the prevalence of chronic pain in different regions of China. Data on pain and its treatment were collected from 9357 participants using questionnaires and telephone-based interviews, from 31 regions of China. Gathered data were then coded into electronic data acquisition system and descriptive and inferential statistical analysis was performed. Out of 9298 participants, the ratio of chronic pain was 31.54% with the proportion of male having chronic pain (33.86%) was higher than that of female (29.53%). The average age of participants with pain (45.02 ± 15.07 years) was higher than f...
Source: Libyan Journal of Medicine - Category: General Medicine Tags: Libyan J Med Source Type: research
Conclusion: Planning, targeting, and controlling of RFA were well supported by MRI with acceptable time. MRI-guided RFA for small HCCs in the hepatic dome is safe and effective with fewer RF sessions. PMID: 32066293 [PubMed - in process]
Source: International Journal of Hyperthermia - Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research
Publication date: Available online 19 February 2020Source: Antiviral ResearchAuthor(s): Anthony T. Tan, Sophia SchreiberAbstractChronic hepatitis B virus (HBV) infection remains a major global concern due to its high prevalence and the increased probability of progressing toward cirrhosis and hepatocellular carcinoma (HCC). While currently available therapies are effective in controlling HBV replication, they rarely achieve functional cure. Similarly, effective treatment options for HBV-related HCC (HBV-HCC) are limited and primarily applicable only for early stages of the disease. With the general success of chimeric anti...
Source: Antiviral Therapy - Category: Virology Source Type: research
Publication date: Available online 18 February 2020Source: Antiviral ResearchAuthor(s): Shu Shi, Mingchen Liu, Jingyuan Xi, Hui Liu, Guiwen Guan, Congle Shen, Zhengyang Guo, Ting Zhang, Qiang Xu, Dilidaer kudereti, Xiangmei Chen, Jie Wang, Fengmin LuAbstractHepatitis B virus (HBV) infection is still a health care crisis in the world, and a considerable number of chronic hepatitis B patients die of end-stage liver diseases, including liver cirrhosis and hepatocellular carcinoma. A previous study has reported that sex-determining region Y box 4 (SOX4) promotes HBV replication by binding to the AACAAAG motif in the viral geno...
Source: Antiviral Therapy - Category: Virology Source Type: research
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