Ischemia-related changes of fat-mass and obesity-associated protein expression in the gerbil hippocampus

AbstractFat-mass and obesity-associated protein (Fto) plays important roles in energy metabolism. It also acts as a demethylase and is most abundantly found in the brain. In the present study, we examined the spatial and temporal changes of Fto immunoreactivity after five minutes of transient forebrain ischemia in the hippocampus. In the control group, Fto immunoreactivity was mainly observed in the nucleus of pyramidal cells in the CA1 and CA3 regions as well as the polymorphic layer, granule cell layer, and subgranular zone of the dentate gyrus. Fto immunoreactivity was transiently, but not significantly, increased in the hippocampal CA3 region and the dentate gyrus two days after ischemia compared to mice without ischemia in the sham-operated group. Four days after ischemia, low Fto immunoreactivity was observed in the stratum pyramidale of the CA1 region because of neuronal death, but Fto immunoreactive cells were abundantly detected in the stratum pyramidale of the CA3 region, which is relatively resistant to ischemic damage. Thereafter, Fto immunoreactivity progressively decreased in the hippocampal CA1 and CA3 regions and the dentate gyrus until ten days after ischemia. At this time-point, Fto immunoreactivity was significantly lower in the hippocampal CA1 and CA3 regions and the dentate gyrus compared to that in the sham-operated group. The reduction of Fto immunoreactive structures in the hippocampus may be associated with impairments in Fto-related hippocampal funct...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research

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ConclusionsPatients with CMS were more likely to present with increased comorbidities. Patients with CMS undergoing CABG were at risk for worse short ‐term secondary postoperative outcomes and reduced long‐term survival. The data supports the need for further investigation for risk reduction surrounding operative revascularization.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conditions:   Cardiovascular Diseases;   Sarcopenic Obesity Interventions:   Other: High-Protein Mediterranean Diet;   Other: Resistance Exercise;   Other: Standard Dietary Advice;   Other: Standard Cardiac Rehabilitation Exercise Sponsors:   Liverpool John Moores University;   University of Chester Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Psoriasis;   Atherosclerotic Cardiovascular Disease;   Obesity;   Dyslipidemia;   Cardiometabolic Diseases Interventions:   Dietary Supplement: Niagen;   Other: Placebo Sponsor:   National Heart, Lung, and Blood Institute (NHLBI) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
I was skeptical, but it turns out there is something to be said for a daily fast, preferably one lasting at least 16 hours.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Obesity Weight Diet and Nutrition Food Source Type: news
SummaryBackgroundPharmacological treatment options for adolescents with obesity are very limited. Glucagon ‐like‐peptide‐1 (GLP‐1) receptor agonist could be a treatment option for adolescent obesity.ObjectiveTo investigate the effect of exenatide extended release on body mass index (BMI) ‐SDS as primary outcome, and glucose metabolism, cardiometabolic risk factors, liver steatosis, and other BMI metrics as secondary outcomes, and its safety and tolerability in adolescents with obesity.MethodsSix ‐month, randomized, double‐blinded, parallel, placebo‐controlled clinical trial in patients (n = 44, 10‐18&thin...
Source: Pediatric Obesity - Category: Eating Disorders & Weight Management Authors: Tags: ORIGINAL RESEARCH Source Type: research
(Columbia University Irving Medical Center) A new study suggests that for women, poor sleep could contribute to unhealthy food choices, increasing the risk of obesity and heart disease.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Source: Obesity Surgery - Category: Surgery Source Type: research
Source: Obesity Surgery - Category: Surgery Source Type: research
AbstractBackgroundRisk factors for heart disease include arterial hypertension, high cholesterol, tobacco abuse, and obesity. There is a paucity of data regarding role of ethnicity in bariatric surgery (BS) outcomes. The study ’s aim is to determine if ethnicity plays a significant role in BS outcomes, heart age, and cardiovascular risk.MethodsWe conducted a retrospective review of data collected concurrently from patients who underwent BS from 2010 to 2015. We analyzed demographics, comorbidities, heart age, and cardiovascular risk-score at surgery and 12-month follow-up. Ethnicities categorized were Caucasian and A...
Source: Obesity Surgery - Category: Surgery Source Type: research
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