New Drug Tepezza (teprotumumab) Could Help Stop Blindness From Thyroid Eye Disease

WEDNESDAY, Jan. 22, 2020 -- The newly approved drug teprotumumab can offer hope to adults with thyroid eye disease, a rare and potentially blinding condition. It's the first treatment specifically approved for thyroid eye disease. The drug was...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news

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Dr. Wallace is Director of Vision Sciences and Chair of the Vision Science Research Program at the Toronto Western Research Institute/University Health Network. She holds appointments in the Departments of Ophthalmology and Vision Sciences and Laboratory Medicine and Pathobiology, University of Toronto. A molecular and developmental biologist by training, she is recognized for her work on the role of Hedgehog signaling in neural progenitor proliferation in the central nervous system. Her lab is now applying this knowledge towards investigating the role of morphogen signaling in tumorigenesis and the development of cell-bas...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
Usher syndrome (USH) is the most prevalent cause of the human genetic deafness and blindness. USH type II (USH2) is the most common form of USH, and USH2A is the major pathogenic gene for USH2. For expanding the ...
Source: BMC Ophthalmology - Category: Opthalmology Authors: Tags: Research article Source Type: research
Publication date: Available online 21 February 2020Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Elisa Castaldi, Claudia Lunghi, Maria Concetta MorroneAbstractBetween 1-5:100 people worldwide have never experienced normotypic vision due to a condition called amblyopia, and about 1:4000 suffer from inherited retinal dystrophies that progressively lead to blindness. While a wide range of technologies and therapies are being developed to restore vision, a fundamental question still remains unanswered: would the adult visual brain retain a sufficient plastic potential to learn how to ‘see’ after a prolo...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
Authors: Merrigan SL, Park B, Ali Z, Jensen LD, Corson TW, Kennedy BN Abstract Aberrant ocular angiogenesis can underpin vision loss in leading causes of blindness, including neovascular age-related macular degeneration and proliferative diabetic retinopathy. Current pharmacological interventions require repeated invasive administrations, may lack efficacy and are associated with poor patient compliance and tachyphylaxis. Vitamin D has de novo anti-angiogenic properties. Here, our aim was to validate the ocular anti-angiogenic activity of biologically active vitamin D, calcitriol, and selected vitamin D analogue, 2...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
AbstractIntroductionThe survival of preterm babies has increased worldwide, but the risk of neuro-developmental disabilities remains high, which is of concern to both the public and professionals. The early identification of children at risk of neuro-developmental disabilities may increase access to intervention, potentially influencing the outcome.AimsNeuroprem is an area-based prospective cohort study on the neuro-developmental outcome of very low birth weight (VLBW) infants that aims to define severe functional disability at 2  years of age.MethodsSurviving VLBW infants from an Italian network of 7 neonatal inten...
Source: Italian Journal of Pediatrics - Category: Pediatrics Source Type: research
Conclusion: Inadequate treatment and control of trachoma treatment showed an association with socioeconomic variables and follow-up of primary care. Health education activities were not accessible to the entire community, indicating the need for more involvement by primary care professionals .
Source: Revista Brasileira de Epidemiologia - Category: Epidemiology Source Type: research
In this study, we developed surface modified poly(lactic acid) (PLA) electrospun nanofibrous membranes (EFMs) with silver nanoparticles (AgNPs) and cellulose nanofibrils (CNF) as scaffolds for cell proliferation and antimicrobial application. The AgNPs with a very low content (below 0.1%) were easily anchored on the surface of PLA EFMs by CNF, which endowed the scaffold with hydrophilicity and antibacterial ability. The in-vitro cell co-culture experiments showed that the scaffold had great biocompatibility to ocular epithelial cells, especially the scaffolds coated by CNF, which significantly proliferated cells. Furthermo...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 20 February 2020Source: Neuroscience LettersAuthor(s): Jan Cendelin, Filip TichanekAbstractLurcher mutant mice of the C3H strain provide a model of both cerebellar and retinal degeneration. They enable the study of the behavior of cerebellar mutants under disabled visual orientation conditions. We aimed to examine cerebellar Lurcher mutants and wild type mice with intact cerebella with and without retinal degeneration employing the rotarod and Morris water maze tests. The positions of the hidden platform and the starting point in the water maze test were stable so as to enable the use of ...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Abstract Posterior reversible encephalopathy (PRES) is a clinical syndrome characterized by headaches, seizures, cortical blindness, and altered mental status up to coma and by a radiological syndrome defined by edematous alteration on Magnetic Resonance Imaging (MRI)-Scans of the white matter. In the following, we present the case of a 73 years old post-operative patient with PRES in the context of hypertension and endocarditis with E. coli. The initial presentation included a series of seizures, sopor, and cortical blindness. In MRI-Scans a marked cerebral edema could be identified. After successful tr...
Source: Der Nervenarzt - Category: Neurology Authors: Tags: Nervenarzt Source Type: research
We report here an 11-year-old boy with acute promyelocytic leukemia who developed ATRA-induced PTC during leukemia treatment. MRI findings beneficial for the diagnosis of PTC were observed.
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Radiology Corner Source Type: research
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