Association of HLA-A*11:01 with sulfonamide-related severe cutaneous adverse reactions in Japanese patients

Sulfonamides are pharmaceuticals with an SO2-NH2 group, used mainly for treating infectious and inflammatory diseases. Their main active ingredient is sulfanilamide (SN), a metabolite that can inhibit folic acid synthesis in bacteria. In Japan, common sulfonamides include sulfamethoxazole (SMX) and salazosulfapyridine (SASP). Sulfonamides can cause severe cutaneous adverse reactions (SCARs), including Stevens –Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug-induced hypersensitivity syndrome (DIHS) (Schnyder and Pichler, 2013).

Source: Journal of Investigative Dermatology - January 21, 2020 Category: Dermatology Authors: Ryosuke Nakamura, Takeshi Ozeki, Noriaki Hirayama, Akihiro Sekine, Taiki Yamashita, Yoichi Mashimo, Yoshiko Mizukawa, Tetsuo Shiohara, Hideaki Watanabe, Hirohiko Sueki, Kohei Ogawa, Hideo Asada, Nahoko Kaniwa, Eri Tsukagoshi, Kayoko Matsunaga, Hiroyuki N Tags: Letters to the Editor Source Type: research