Identification of a human skin commensal bacterium that selectively kills Cutibacterium acnes

The microbiome represents a vast resource for drug discovery as its members engage in constant conflict to outcompete one another by deploying diverse strategies for survival. Cutibacterium acnes (C. acnes) is one of the most common bacterial species on human skin and can promote the common disease acne vulgaris. By employing a combined strategy of functional screening, genetics and proteomics we discovered a strain of Staphylococcus capitis (S. capitis E12) that selectively inhibited growth of C.

Source: Journal of Investigative Dermatology - January 21, 2020 Category: Dermatology Authors: Alan M. O ’Neill, Teruaki Nakatsuji, Asumi Hayachi, Michael R. Williams, Robert H. Mills, David J. Gonzalez, Richard L. Gallo Tags: Original Article Source Type: research