A randomized controlled trial of 5 daily sessions and continuous trial of 4 weekly sessions of repetitive transcranial magnetic stimulation for neuropathic pain

We conducted a multicenter, randomized, patient- and assessor-blinded, sham-controlled trial to investigate the efficacy of repetitive transcranial magnetic stimulation (rTMS) of the primary motor cortex (M1) in patients with neuropathic pain (NP). Patients were randomly assigned to receive 5 daily sessions of active or sham rTMS of M1 corresponding to the part of the body experiencing the worst pain (500 pulses per session at 5 Hz). Responders were invited to enroll in an open-label continuous trial involving 4 weekly sessions of active rTMS. The primary outcome was a mean decrease in a visual analogue scale of pain intensity (scaled 0-100 mm) measured daily during the daily sessions in an intention-to-treat population. Secondary outcomes were other pain scores, quality-of-life measures, and depression score. One hundred forty-four patients were assigned to the active or sham stimulation groups. The primary outcome, mean visual analogue scale decreases, was not significantly different (P = 0.58) between the active stimulation group (mean, 8.0) and the sham group (9.2) during the daily sessions. The secondary outcomes were not significantly different between 2 groups. The patients enrolled in the continuous weekly rTMS achieved more pain relief in the active stimulation group compared with the sham (P
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research

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CONCLUSIONS: We found DEGs and DEMs in FM patients through bioinformatics analysis, which may be involved in the occurrence and development of FM and serve as potential targets for diagnosis and treatment. PMID: 32083545 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Grief and Loss Mindfulness Self-Help Bereavement grieving Source Type: blogs
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Source: EXPLORE: The Journal of Science and Healing - Category: Complementary Medicine Source Type: research
We describe the supportive medications used by treatment-na ïve lung cancer patients and assess their association with PROs from MD Anderson Symptom Inventory (MDASI).MethodsTreatment-na ïve lung cancer patients who completed PROs from MDASI at the initial visit to MD Anderson Cancer Center were included. Medications from the initial visit were abstracted from the electronic medical records system and categorized into therapeutic classes based on U.S. Pharmacopeia v7.0. A chi-squar e or Mann-WhitneyU test was conducted as appropriate.ResultsAmong 459 patients, ~  50% took any analgesics and 25% were on opi...
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
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Source: Current Orthopaedic Practice - Category: Orthopaedics Tags: Original Research Source Type: research
Conclusions Together, these results showed that the ECT-PK is an efficient and effective contemporary tool to measure the perception and knowledge of ECT, and highlights areas in need of psychoeducation.
Source: The Journal of ECT - Category: Psychiatry Tags: Original Study Source Type: research
The health tracking market is booming. What with smart bracelets, smart beds and smart chest straps, the tracking industry has penetrated the lives of old and young from the time they wake up in the morning to the time they hit the bed at night (and beyond). It’s no wonder that user penetration is projected to reach 25% of the adult population by 2022 in the US alone and that these devices are being adopted by over 30% of individuals across all age groups. Naturally, I count among those adopters. I call myself a data geek, using the data accumulated from myriads of health trackers to help me make more informed hea...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Health Sensors & Trackers digital health digital technology health data digital health sensors Source Type: blogs
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Source: Libyan Journal of Medicine - Category: General Medicine Tags: Libyan J Med Source Type: research
PMID: 32068588 [PubMed - in process]
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
Abstract In 2011, Florida established a Prescription Drug Monitoring Program and adopted new regulations for independent pain-management clinics. This paper examines the association of those reforms with drug overdose deaths and other injury fatalities. Florida's post-reform monthly mortality rates - for drug-involved deaths, motor vehicle crashes, and suicides by means other than poisoning - were compared to a counterfactual estimate of what those rates would have been absent reform. The counterfactual was estimated using a Bayesian structural time-series model based on mortality trends in similar states. By Dece...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research
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