Oh no! Are we all going to die?

Yes. However, very probably not because of the novel coronavirus that has appeared in China. This seems to be front page headlines in every media outlet on the planet, and  the World Health Organization has convened a meeting to decide whether to declare an official Global Health Emergency.This sort of flapdoodle happens every time a novel pathogen appears. Back when I lived in the Hub of the Universe a mosquito-borne disease called West Nile virus appeared (having formerly been large confined to, yes, west of the Nile). For weeks, every time a new case was identified it would be on the front page of the Boston Globe. The Commissioner of Public Health sprayed Boston's residential neighborhoods with insecticide, killing of course every arthropod in the air column but probably not very many mosquitoes.Now here's the thing about West Nile virus. The large majority of people who are infectedhave no symptoms at all, but derive life-long immunity. The vast majority of the rest have mild symptoms and probably think they just had a cold. They also derive life-long immunity. In rare cases, people develop meningitis, which even more rarely may go on to become serious causing permanent neural damage or death. Well, West Nile virus has no been in the U.S. for more than a decade and we've pretty much forgotten all about it because as public health problems go, it is utterly trivial. Far more people are seriously sickened or die from all sorts of other pathogens which we don't worry a...
Source: Stayin' Alive - Category: American Health Source Type: blogs

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Conclusion: Taken together, these results suggest that SXD maybe alleviate EMT in DN via the inhibition of the TGF-β1/Smad/RUNX3 signaling pathway under hyperglycemic conditions.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 21 February 2020Source: Antiviral ResearchAuthor(s): Rashmi Kumari, Zhu Guo, Amrita Kumar, Mayim Wiens, Shivaprakash Gangappa, Jacqueline M. Katz, Nancy J. Cox, Renu B. Lal, Devanand Sarkar, Paul B. Fisher, Adolfo García-Sastre, Takashi Fujita, Vijay Kumar, Suryaprakash Sambhara, Priya Ranjan, Sunil K. LalAbstractInfluenza virus non-structural protein 1 (NS1) counteracts host antiviral innate immune responses by inhibiting Retinoic acid inducible gene-I (RIG-I) activation. However, whether NS1 also specifically regulates RIG-I transcription is unknown. Here, we identify a CCAAT/Enh...
Source: Antiviral Therapy - Category: Virology Source Type: research
Publication date: Available online 21 February 2020Source: Carbohydrate PolymersAuthor(s): Jun Zhang, Zewen Mei, Xingxi Huang, Yueyue Ding, Yunxiang Liang, Yuxia MeiAbstractA low-molecular-weight chitosan (LMWC) sample was prepared by enzymatic hydrolysis, and used for investigation of special Maillard reaction products (MRPs) and factors affecting LMWC bioactivities. After undergoing MR, LMWC turned to brown color (termed BLMWC), showed reduction of several indices of rice growth promotion. This alteration of bioactivities was attributable to MRPs in BLMWC. A special MRP, 5-hydroxy-2-pyridine methanol isomer (5-H-2PMIS), ...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 21 February 2020Source: Chinese Chemical LettersAuthor(s): Chaonan Gu, Jingjing Li, Guang Yang, Liming Zhang, Chun-Sen Liu, Huan PangAbstractThis work introduces a simple and facile approach for the morphology and size controlled synthesis of Co-doped MIL-96. Using different bases as modulators, Co-doped MIL-96 was obtained with sizes that varied from 5 μm to 300 nm, and four different morphologies, including hexagonal prism, icosahedron, hexagonal spindle and ellipsoid. Among these, nano-sized Co-doped MIL-96 with an ellipsoid morphology exhibited the highest electroacti...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
Publication date: Available online 21 February 2020Source: Chinese Chemical LettersAuthor(s): Shumeng Wu, He Wang, Li Li, Meixia Guo, Zhichong Qi, Qingyou Zhang, Yanmei ZhouAbstractCombining high conductivity, hydrophilicity and excellent electrochemical performance in one, MXenes have attracted increasing attention since their inception. However, easy to stack caused by the van der Waals’ force between the layers limits their practical application. Fortunately, intercalating other substances between layers of MXenes and getting intercalated MXene-based layered composites (IMLCs) with open structure can improve their...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
Publication date: Available online 21 February 2020Source: Chinese Chemical LettersAuthor(s): Lei Zhou, Chang Du, Rong Zhang, Changming DongAbstractWe developed one-pot aqueous copolymerization of two dopamine prodrugs to prepare dual drugs-conjugated polydopamine nanoparticles (PDOXCBs), which integrated near infrared (NIR)-mediated photothermal effect with cocktail chemotherapy into one copolymer nanoparticle. Upon a mild NIR irradiation (808 nm, 1 W/cm2, 10 min), PDOXCBs gradually heated aqueous solution over 12.8―13.9 °C, which accordingly enhanced in vitro dual doxorubicin (DOX) and c...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
Publication date: Available online 21 February 2020Source: Chinese Chemical LettersAuthor(s): Bo Fang, Zong Liu, Yufei Bao, Ligang FengAbstractSignificance of unstable species leaching was for the first time demonstrated on MOF-derived catalysts by taking PtNi-C as an example, that was instructive for the relevant catalyst fabrication and performance study. PtNi-C catalyst was synthesized by combining Pt nanoparticles with Ni-BTC after annealing in the tube furnace and the unstable Ni species can be easily leached out in nitric acid, and the stable PtNi nanoparticles trapped in the graphite carbon layer were obtained. The ...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
Publication date: Available online 21 February 2020Source: Chemical Engineering JournalAuthor(s): Guomin Tang, Yongbing Zhang, Yujiang Wei, Shuang Wang, Pei Liu, Zhehua Jia, Xuemin Yu, Fang MaAbstractThe advanced treatment of biotreated Chinese patent medicine wastewater (BCPMW) was urgently necessitated to meet the strictest wastewater discharge standard. In the present study, combined ozone/peroxymonosulfate oxidation and upflow biological aerated filter process (O3/PMS-UBAF) significantly integrated advantages of O3/PMS oxidation and UBAF, and has been demonstrated to be very effective in the advanced treatment of BCPMW...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
CONCLUSIONS: Given increasing rates of opioid addiction and death, viable solutions are universally needed. Successful intervention measures should be widely shared between military, veteran, and civilian healthcare and public health communities. Increased collaboration between these groups could inculcate successful programs to prevent and decrease opioid use. Results received from recent military and veterans' programs for prescription and electronic medical record (EMR) monitoring and data sharing may also prove useful for civilian healthcare providers and hospital systems. Future evaluations from ongoing federally fund...
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
This article aims to explore the differences in rhetorical preferences between independently produced English and Chinese research article abstracts and the strategies used in translating Chinese RAAs into English. RAAs published in three journals between 2006 and 2016 were selected to form three corpora: corpus A consisting of 32 English RAAs, corpus B made up of 38 Chinese RAAs, and corpus C including 38 English RAAs which are translations of the RAAs in corpus B. Corpus A and B form a comparable corpus while corpus B and C constitute a parallel corpus. Results suggest that Chinese and English RAAs have different prefere...
Source: Lingua - Category: Speech-Language Pathology Source Type: research
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