Identification and characterization of protective CD8+ T ‐epitopes in a malaria vaccine candidate SLTRiP

ConclusionOur findings show that the protective efficacy shown by SLTRiP is localized in particular protein fragments. The peptides designed from such regions showed protective efficacy equivalent to whole protein. The sequence conservation analysis with humanPlasmodium species also showed that these peptides were conserved. In conclusion, these peptides or their equivalent from otherPlasmodium species could impart protection against malaria in their respective hosts too. Our studies provide a basis for the inclusion of these peptides in clinical vaccine constructs against malaria.
Source: Immunity, Inflammation and Disease - Category: Allergy & Immunology Authors: Tags: ORIGINAL RESEARCH Source Type: research