Evaluation of hypersensitivity reactions to cancer chemotherapeutic agents in pediatric patients

Hypersensitivity reactions(HSR) to chemotherapeutic agents have been increasingly documented.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research

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AbstractMast cells (MCs) are granular cells of the innate immune system which develop from CD34+/CD117+ progenitors and play a role in orchestrating adaptive immune responses. They have a well-known role in allergic reactions following immunoglobulin (Ig)E-mediated activation of the cell-surface expressed IgE high-affinity receptor (Fc εRI). MCs can also respond to various other stimuli due to the expression of a variety of receptors including toll-like receptors (TLRs), immunoglobulin (IgG) receptors (FcγR), complement receptors such as C5a (CD88) expressed by skin MCs, neuropeptides receptors including nerv...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
This study establishes baseline sociodemographic and clinical characteristics of hospitalized patients in Nepal who were experiencing heart failure.     Read more   Maternal Health ...
Source: Johns Hopkins University and Health Systems Archive - Category: Nursing Source Type: news
Airway hyperresponsiveness (AHR) is associated with an increased mortality risk among males [1] and chronic obstructive pulmonary disease (COPD) patients [2]. However, this association is largely based on cross-sectional studies using a single measurement of AHR to predict mortality; inherently ignoring the longitudinal variability of AHR. AHR is variable regardless of disease or medication status, and is linked with changes in smoking habits, seasonal variations and exposure to pollutants [3–5]. Considering this, it remains unclear how changes in AHR affect mortality, specifically from causes such as COPD, cardiovas...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Asthma and allergy Original Articles: Research letters Source Type: research
ConclusionOur study does not support a causal effect of allergic disease on the risk of breast or prostate cancer. Future studies may be conducted to focus on understanding the causal role of allergic disease in cancer prognosis or drug responses (e.g., immunotherapy).
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
This article is protected by copyright. All rights reserved. PMID: 31991477 [PubMed - as supplied by publisher]
Source: European Journal of Immunology - Category: Allergy & Immunology Authors: Tags: Eur J Immunol Source Type: research
Abstract Sialic acid-binding immunoglobulin-type lectins (Siglecs) are expressed on the majority of white blood cells of the immune system and play critical roles in immune cell signaling. Through recognition of sialic acid-containing glycans as ligands, they help the immune system distinguish between self and nonself. Because of their restricted cell type expression and roles as checkpoints in immune cell responses in human diseases such as cancer, asthma, allergy, neurodegeneration, and autoimmune diseases they have gained attention as targets for therapeutic interventions. In this review we describe the Siglec ...
Source: Annual Review of Immunology - Category: Allergy & Immunology Authors: Tags: Annu Rev Immunol Source Type: research
CONCLUSION: Among all chemotherapeutic agents reviewed in our study which caused HSRs, asparaginase was the most co. PMID: 31981613 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Ann Allergy Asthma Immunol Source Type: research
CONCLUSION: In conclusion, chitinases can be used as potential biomarkers in prognosis and diagnosis of several inflammatory diseases and allergies and the design of novel chitinase inhibitors may act as key and rational scaffolds in designing of some novel therapeutic agents in the treatment of variety of inflammatory diseases. PMID: 31934842 [PubMed - as supplied by publisher]
Source: Recent Patents on Inflammation and Allergy Drug Discovery - Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research
Publication date: March 2020Source: Biomedicine &Pharmacotherapy, Volume 123Author(s): Abdolreza Esmaeilzadeh, Safa Tahmasebi, Seyyed Shamsadin AthariAbstractDespite the current advancements, cancer treatment approaches have limitations restricting their cure rate. Immunotherapy techniques are among novel and promising cancer therapeutic approaches. Therapeutic antibodies and adoptive cell therapy (ACT) are the main branches of immunotherapy. T lymphocytes and genetically engineered cells are among important cells which can be used in ACT. This review has focused on recent advances in engineered cell-based immunotherap...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
The immune system is increasingly recognized as a key player in glioma pathobiology. Small case ‐control studies have found inverse associations between autoimmune diseases and glioma incidence. We performed a large case‐control study, which did not replicate these associations. However, our data indicate that inflammatory bowel disease (IBD) among patients ≤40 years are associated with an increased risk of glioma. Further studies are needed to explore the role of IBD and altered microbiota in glioma. AbstractEffectors from the immune system can modulate the course and possibly the early development of gliomas....
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
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