Comparison of serum microbiome composition in bipolar and major depressive disorders

In conclusion, the Prevotella 2 and Ruminococcaceae UCG-002 genera were identified as potential candidates for distinguishing bipolar disorder and major depressive disorder. Further studies with larger sample sizes, longitudinal designs, and control for other various confounders are warranted.
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research

Related Links:

Conclusions: Certain modifiable risk factors play an inescapable role in increasing the level of burden among caregivers of older patients with serious mental illnesses.Clinical Implications: Improving the quality of life and psychological well-being of family caregivers should be considered an integral part of treatment for serious mental illness in older adult patients. PMID: 32058858 [PubMed - as supplied by publisher]
Source: Clinical Gerontologist - Category: Geriatrics Tags: Clin Gerontol Source Type: research
The objective of this study is to track and compare acute manic symptoms for sex differences during inpatient hospitalization.MethodsAll patients with bipolar mania admitted to a large university hospital between January and October 2017 were invited to participate in this longitudinal naturalistic follow ‐up study. Manic (YMRS), depressive (MADRS), and psychotic (PAS) symptoms were tracked daily from admission to discharge.ResultsThe total YMRS scores decreased significantly overtime (p 
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
AbstractThere is increasing evidence from genetic, biochemical, pharmacological, neuroimaging and post-mortem studies that immunological dysregulation plays a crucial role in the pathogenesis of psychoses. The involvement of microglia in schizophrenia and bipolar disorder (BD) has remained controversial, however, since results from various post-mortem studies are still inconclusive. Here, we analyzed the estimated density of microglia of age-matched individuals with schizophrenia (n = 17), BD (n = 13), and non-psychiatric control subjects (n = 17) in the anterior midcingulate corte...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Neuroscience Source Type: research
This article summarizes the milestones in the development of lumateperone leading to this first approval for the treatment of schizophrenia.
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
AbstractThere is increasing evidence to support the notion that oligodendrocyte and myelin abnormalities may contribute to the functional dysconnectivity found in the major psychiatric disorders. The putamen, which is an important hub in the cortico –striato–thalamo–cortical loop, has been implicated in a broad spectrum of psychiatric illnesses and is a central target of their treatments. Previously we reported a reduction in the numerical density of oligodendrocytes and oligodendrocyte clusters in the prefrontal and parietal cortex in sc hizophrenia. Oligodendrocyte clusters contain oligodendrocyte proge...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Neuroscience Source Type: research
This study aimed to investigate the association between anticholinergic medications and the risk of dementia using data from Taiwan's National Health Research Database (NHIRD).MethodsA total of 790,240 patients, with 197,560 patients receiving anticholinergic medications and 592,680 control patients (1:3) matched for sex, age, and index-year, were enrolled from the two million Longitudinal Health Insurance Dataset, a subdataset of the NHIRD, between 2000 and 2015. The time-dependent Cox regression analysis was used to explore the hazard ratio (HR) with a 95% confidence interval for the association between anticholinergics ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
I was a third-year medical student when I discovered my calling to become a psychiatrist. To this day, I remember the gentleman who changed the trajectory of my life.  He was a middle-aged individual who presented to the clinic due to difficulties with depression. As I entered the exam room, I remember feeling uneasy by the magnitude of his suffering. I could not see his eyes as he slumped over his chair resting his head in his hands. He spoke very slowly as he mustered the strength to answer my questions. The interview lagged with noticeable pauses in his answers. His answers were brief, but his suffering was pervasi...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Inspiration & Hope Personal Policy and Advocacy Psychiatry Stigma discrimination Mental Illness Stigmatization Source Type: blogs
Does the new coronavirus from China make you a little anxious? How concerned should we be? Is it a real threat or mostly hype? In today’s podcast, Dr. John Grohol, founder and editor-in-chief of, explains what the coronavirus is, how it compares to the flu and why it seems to have hit the panic button in a lot of people. He offers tips to avoid getting sick in general, and importantly, gives advice on how to keep our anxiety levels in check when it comes to new disease outbreaks, especially in how we seek information from the media. If you’d like to learn more about the coronavirus and how to...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anxiety and Panic Disorders General Health-related Interview Podcast The Psych Central Show Source Type: blogs
AbstractBackground and purposeIn the group of severe mental disorders, psychotic depression (PD) is essentially under-researched. Knowledge about the risk factors is scarce and this applies especially to early risk factors. Our aim was to study early childhood and adolescent risk factors of PD in a representative birth cohort sample with a follow-up of up to 50  years.MethodsThe study was carried out using the Northern Finland Birth Cohort 1966 (NFBC 1966). We used non-psychotic depression (NPD) (n = 746), schizophrenia (SZ) (n = 195), psychotic bipolar disorder (PBD) (n = 27)...
Source: Social Psychiatry and Psychiatric Epidemiology - Category: Psychiatry Source Type: research
So in digging around the Spravato website and seeing whose getting on their directory in different places in the country, I made the mistake of looking up Portland, OR and saw a bunch of naturopathic doctors on the list. That in itself is concerning, a ND is prescribing Esketamine Spray, for depression patients. But it doesn't stop there, I looked up one website: "...We work with a variety of conditions including depression, anxiety, bipolar disorder, ADHD, psychosis, schizophrenia, OCD... Naturopathic Doctor
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Psychiatry Source Type: forums
More News: Bipolar | Databases & Libraries | Depression | Genetics | Mania | Psychiatry | Statistics | Study