Brain tumor classification using a hybrid deep autoencoder with Bayesian fuzzy clustering-based segmentation approach

Publication date: Available online 21 January 2020Source: Biocybernetics and Biomedical EngineeringAuthor(s): P.M. Siva Raja, Antony Viswasa raniAbstractIn medical image processing, brain tumor detection and segmentation is a challenging and time-consuming task. Magnetic Resonance Image (MRI) scan analysis is a powerful tool in the recent technology that makes effective detection of the abnormal tissues from the brain. In the brain image, the size of a tumor can be varied for different patients along with the minute details of the tumor. It is a difficult task to diagnose and classify the tumor from numerous images for the radiologists. This paper developed a brain tumor classification using a hybrid deep autoencoder with a Bayesian fuzzy clustering-based segmentation approach. Initially, the pre-processing stage is performed using the non-local mean filter for denoising purposes. Then the BFC (Bayesian fuzzy clustering) approach is utilized for the segmentation of brain tumors. After segmentation, robust features such as, information-theoretic measures, scattering transform (ST) and wavelet packet Tsallis entropy (WPTE) methods are used for the feature extraction process. Finally, a hybrid scheme of the DAE (deep autoencoder) based JOA (Jaya optimization algorithm) with a softmax regression technique is utilized to classify the tumor part for the brain tumor classification process. The proposed scheme is implemented in a MATLAB environment. The simulation results are conduct...
Source: Biocybernetics and Biomedical Engineering - Category: Biomedical Engineering Source Type: research

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Conclusion: Four immunophenotypes were found in GBM vessels, corresponding to endotheliocytes, Pcs, Tcs, and a mixed Pc/Tc immunophenotype. These and forthcoming improvements in our understanding of the origin and function of Tcs, including their relationship with Pcs, are necessary steps in oncology. Study of these cell types (Tcs, Pcs) and their roles in brain tumor oncogenesis will likely enable improved targeted therapies and support development of new forms of anti-neoplastic drugs. PMID: 32064038 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
CONCLUSION: The results of the present study showed that the measurement of retinal nerve fiber layer thickness was the most efficient test for discriminating patients with and without optic pathway glioma. Brain magnetic resonance imaging remains the gold standard to confirm the diagnosis of optic pathway glioma. Longitudinal studies are required to define if the early detection of tumors with optical coherence tomography could prevent vision loss and morbidity. PMID: 32066268 [PubMed - as supplied by publisher]
Source: European Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Eur J Ophthalmol Source Type: research
CONCLUSIONS: Taken together, these results represent the first full characterization of an Auger-emitting PARP inhibitor which demonstrate a survival benefit in mouse models of GBM and confirm the high potential of 123 I-MAPi for clinical translation. PMID: 32066626 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
AbstractPurposeRadiotherapy is a frequently applied treatment modality for brain tumors. Concomitant irradiation of normal brain tissue can induce various physiological responses. The aim of this study was to investigate whether acute and early-delayed effects of brain irradiation on glial activation and brain metabolism can be detected with positron emission tomography (PET) and whether these effects are correlated with behavioral changes.ProceduresRats underwent 0-, 10-, or 25-Gy whole-brain irradiation. At 3 and 31  days post irradiation, 1-(2-chlorophenyl)-N-[11C]methyl-(1-methylpropyl)-3-isoquinoline carboxamide ...
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
AbstractThe grading of glioma has clinical significance in determining a treatment strategy and evaluating prognosis to investigate a novel set of radiomic features extracted from the fractional anisotropy (FA) and mean diffusivity (MD) maps of brain diffusion tensor imaging (DTI) sequences for computer-aided grading of gliomas. This retrospective study included 108 patients who had pathologically confirmed brain gliomas and DTI scanned during 2012 –2018. This cohort included 43 low-grade gliomas (LGGs; all grade II) and 65 high-grade gliomas (HGGs; grade III or IV). We extracted a set of radiomic features, including...
Source: Journal of Digital Imaging - Category: Radiology Source Type: research
Publication date: Available online 5 February 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Ana Margarida Abrantes, Ana Salomé Pires, Lúcia Monteiro, Ricardo Teixo, Ana Rita Neves, Nuno Tiago Tavares, Inês Alexandra Marques, Maria Filomena BotelhoAbstractCarcinogenesis is a complex multistep process, characterized by changes at different levels, both genetic and epigenetic, which alter cell metabolism. Positron emission tomography (PET) is a very sensitive image modality that allows to evaluate oncometabolism. PET functionalities are immense, since by labelling a...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
ConclusionOur study shows that patients who received cranial irradiation were at risk of secondary brain tumors such as cavernomas and meningiomas. Thus, a meticulous follow-up of cancer survivors with history of cranial irradiation by an annual MRI scan is justifiable. This will help clinicians to detect secondary brain tumors early and make its management much easier.
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
Cai Glioblastoma multiforme (GBM) is the deadliest type of brain tumor, affecting approximately three in 100,000 adults annually. Positron emission tomography (PET) imaging provides an important non-invasive method of measuring biochemically specific targets at GBM lesions. These powerful data can characterize tumors, predict treatment effectiveness, and monitor treatment. This review will discuss the PET imaging agents that have already been evaluated in GBM patients so far, and new imaging targets with promise for future use. Previously used PET imaging agents include the tracers for markers of proliferation ([11C...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
ConclusionsThe results reinforce that [18F]FGln has preferential uptake in glioma tissueversus that of corresponding healthy tissue and fits well with reversible uptake models.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
Conditions:   Brain Tumor;   Glioma;   IDH Mutation Intervention:   Device: MR-scans using a 3T Prisma and a 7T Terra scanner (Siemens, Erlangen Germany) Sponsors:   University Hospital Inselspital, Berne;   Swiss National Science Foundation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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