Impact of Triptolide during Ex Vivo Lung Perfusion on Grafts After Transplantation in a Rat Model

Ex vivo lung perfusion (EVLP) creates a proinflammatory environment leading to deterioration in graft quality which may contribute to posttransplant graft dysfunction. Triptolide has been shown to have a therapeutic potential in various disease states due to its anti-inflammatory properties. Based on this, we investigated the impact of Triptolide on graft preservation during EVLP as well as associated post-transplant outcomes in a rat transplant model.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research