Impact of Triptolide during Ex Vivo Lung Perfusion on Grafts After Transplantation in a Rat Model
Ex vivo lung perfusion (EVLP) creates a proinflammatory environment leading to deterioration in graft quality which may contribute to posttransplant graft dysfunction. Triptolide has been shown to have a therapeutic potential in various disease states due to its anti-inflammatory properties. Based on this, we investigated the impact of Triptolide on graft preservation during EVLP as well as associated post-transplant outcomes in a rat transplant model.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Sarah Burki, Kentaro Noda, Brian J. Philips, Murugesan Velayutham, Sruti Shiva, Pablo G. Sanchez, Ajay Kumar, Jonathan D ’Cunha Source Type: research
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