C - reactive protein and urinary tract infection due to Gram-negative bacteria in a pediatric population at a tertiary hospital, Mwanza, Tanzania

Introduction: Gram-negative bacteria are the major cause of urinary tract infections (UTI) in children. There is limited data on UTI systemic response as measured using C-reactive protein (CRP). Here, we report the association of CRP and UTI among children attending the Bugando Medical Centre, Mwanza, Tanzania.Methods: A cross-sectional study was conducted between May and July 2017. Urine and blood were collected and processed within an hour of collection. Data were analyzed using STATA version 13.Results: Of 250 enrolled children, 76(30.4%) had significant bacteriuria with 56(22.4%, 95%CI; 11.5-33.3) having gram-negative bacteria infection. There was dual growth of gram-negative bacteria in 3 patients. Escherichia coli (32.2%, 19/59) was the most frequently pathogen detected. A total of 88/250(35.2%) children had positive CRP on qualitative assay. By multinomial logistic regression, positive CRP (RRR=4.02, 95%CI: 2.1-7.7, P
Source: African Health Sciences - Category: African Health Source Type: research

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Authors: Mann M, Calio BP, Mark JR, Chelluri R, Hufnagel E, Reese A, Lallas CD, Trabulsi EJ, Chandrasekar T, Shenot PJ, Halpern E, Gomella LG Abstract INTRODUCTION: To assess whether standard American Urological Association (AUA) and other recommendations for prostate biopsy prophylaxis provide sufficient coverage of common urinary organisms responsible for post biopsy infections by comparing local antibiograms in Philadelphia-area hospitals. MATERIALS AND METHODS: De-identified culture results derived from antibiograms were collected from six academic and community hospitals in the Philadelphia region. Analysi...
Source: Canadian Journal of Urology - Category: Urology & Nephrology Tags: Can J Urol Source Type: research
Abstract INTRODUCTION: Epididymo-orchitis is a common urological disease among men. Little is known about the clinical and epidemiological aspects of the disease in Iran. Thus, the present study was aimed to investigate the etiology, clinical sequelae and risk factors of patients with epididymo-orchitis in Tehran, Iran. MATERIALS AND METHODS: Patients presenting with epididymo-orchitis were prospectively analyzed in order to study the etiology and pattern of the disease. Bacteriological, molecular and serological tests were undertaken to look for Chlamydia trachomatis, Neisseria gonorrhoeae, Brucella spp., My...
Source: Infectious Disorders Drug Targets - Category: Infectious Diseases Authors: Tags: Infect Disord Drug Targets Source Type: research
Publication date: Available online 12 February 2020Source: Microbial PathogenesisAuthor(s): Imran Khan, Ashutosh Bahuguna, Shruti Shukla, Faisal Aziz, Anil Kumar Chauhan, Mohd Bismillah Ansari, Vivek K. Bajpai, Yun Suk Huh, Sun Chul KangAbstractThe antibiotic resistance of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli has increased drastically in recent years. In our study, we determined the principle mechanisms of action for the food-grade additive carvacrol against ESBL E. coli isolated from the blood of patients with a urinary tract infection. Carvacrol, which has a minimum inhibitory concentratio...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
ConclusionsIn ESBL-E. coli RUTI, most recurrences were caused by the initial infecting strain. The high frequency of the multidrug-resistant fimH30Rx subclone and its association with multiple recurrences warrants further attention and early detection of this subclone in patients at risk of developing RUTI with ESBL-producing E. coli.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionsOur study shows that fosfomycin-resistantE. coli strains are isolated in the majority of the cases in elderly people with complicated UTIs and belong the pandemic ST131 clone. To our knowledge, we describe, for the first time in Spain, the gene fosA3, which alerts for a future dissemination that should be monitored.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
Antimicrobial resistance in N'Djamena (Chad): Four-year experience of the French Forward Medical and Surgical Team engaged in the "Barkhane Operation". Med Mal Infect. 2020 Feb 05;: Authors: Cardinale M, Bourbotte-Salmon F, Scheiwe C, Boulezaz S, Ridet M, Laitselart P Abstract OBJECTIVES: Knowledge of local antimicrobial resistance (AMR) patterns is required for effective empirical treatment of bacterial diseases. Very little is known about current resistance patterns of common pathogenic bacteria in the African region and particularly in the Sahel region. We aimed to describe the local bacte...
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
ConclusionCirculating MAIT cells in immunocompetent individuals with RUTIs respond to bacterial stimuli with reduced efficacy, which suggests that they are involved in the pathogenesis of RUTIs.
Source: Immunity, Inflammation and Disease - Category: Allergy & Immunology Authors: Tags: ORIGINAL RESEARCH Source Type: research
In conclusion, gas under the diaphragm can be related to non-bowel-related gynaecological pathology, but it vital to rule out sinister causes.
Source: Case Reports in Womens Health - Category: OBGYN Source Type: research
Conclusions:The results of this study showed that the most common resistance are antibiotics that are commonly used. The most effective antibiotics forE. coliwere imipenem, nitrofurantoin, amikacin, chloramphenicol, and ciprofloxacin. Considering this study, it had better, use less gentamicin, second ‑generation cephalosporins, and nalidixic acid in the initial treatment of infections caused byE. coli, and no use penicillins, tetracyclines, cotrimoxazole, and first-generation cephalosporins.Keywords:Antibiotics, antimicrobial resistance, Gram ‑negative bacteria, Gram‑positive bacteria, urinary tract infections
Source: International Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
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