Ghana: Antibiotics Use and Effects On Gut Flora

[Ghanaian Times] There is concern about the effects of irrational use of antibiotics. This is not only because of the issue of antimicrobial resistance but importantly about the effect of antibiotics on the gut microbiota. The digestive tract especially the large intestine is the habitat for millions of microbes living in concert with several functions of the body. Antibiotics have been very useful in treating and controlling infections with positive impact of standard of living.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news

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Publication date: Available online 19 February 2020Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Valéria Cataneli Pereira, Letícia Calixto Romero, Luiza Pinheiro-Hubinger, Adilson Oliveira, Katheryne Benini Martins, Maria de Lourdes Ribeiro de Souza da CunhaAbstractThe increasing rates of nosocomial infection associated with coagulase–negative staphylococci (CoNS) were the rationale for this study, aiming to categorize oxacillin–resistant CoNS species recovered from blood culture specimens of inpatients at the UNESP Hospital das Clínicas in Botucatu, Brazil, over a 20&ndash...
Source: The Brazilian Journal of Infectious Diseases - Category: Infectious Diseases Source Type: research
Publication date: Available online 19 February 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Zhenwei Yu, Lingyan Yu, Jianping Zhu
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionsA. baumannii ST2 producing 16S rRNA methylase ArmA has been spreading in medical settings in Myanmar.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionOverexpression in efflux pump transporter genes together with mutations in ERG11 pave the way to fluconazole resistance among C. tropicalis. To the best of our knowledge this is the first study on C. tropicalis fluconazole resistance mechanism from North India region.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionTigcycline induced changes in the expression of some related genes in A. baumannii, which may be the main reason for its increased drug resistance.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 18 February 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Rayane Rafei, Malaik Hawli, Marwan Osman, Fouad Dabboussi, Monzer HamzeAbstractThis review aimed to provide an updated scenario of the Group A Streptococcus (GAS) epidemiology in the Middle Eastern and North African (MENA) region with a special spotlight on the most prevalent emm types and macrolide resistance profiles. While the burden of invasive GAS infections is elusive to assess in the MENA region, the GAS prevalence ranged from 2.5% to up 42.4% in pharyngitis patients and from 2.4% to up 35.4% in healthy ca...
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionsThe findings showed the presence of antibiotic resistance in probiotic bacteria isolated from commercially available dietary supplements. As multidrug resistance is a serious emerging issue and the risk of drug resistant gene transfer to commensals or pathogens of the gut is inevitable, the safety of probiotics has become a major criterion of interest. The findings of this study would serve as a platform for further screening and characterization of the determinants of antibiotic resistance and the genetic mechanisms of resistance.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionThe corresponding treatment effect estimate for nitrofurantoin was 26.8%, which supports a conservative non-inferiority margin of 12.5% and is consistent with the recently published draft FDA guidance. The findings from this systematic review and meta-analysis inform future antibacterial trials by providing non-inferiority margin justification.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: March 2020Source: Journal of Global Antimicrobial Resistance, Volume 20Author(s): Laura Mazzuti, Taulant Melengu, Francesca Falasca, Marianna Calabretto, Eleonora Cella, Massimo Ciccozzi, Ivano Mezzaroma, Giancarlo Iaiani, Martina Spaziante, Gabriella d’Ettorre, Caterina Fimiani, Vincenzo Vullo, Guido Antonelli, Ombretta TurrizianiAbstractObjectivesTransmitted drug resistance (TDR) and HIV-1 genetic diversity may affect treatment efficacy and clinical outcomes. Here we describe the circulating viral subtypes and estimate the prevalence of drug resistance among antiretroviral therapy (ART)-naïve...
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
This study characterized Listeria monocytogenes, Salmonella enterica, and E. coli O157:H7 by collecting rectoanal mucosal swabs and fecal samples from 518 imported beef cattle at Jordan’s major abattoir. A unique 53 L. monocytogenes, 287 S. enterica, and 17 E. coli O157:H7 were isolated from 37, 120 and 9 different animals; respectively. The prevalence of S. enterica, L. monocytogenes and E. coli O157:H7 were 23.2% (95% CI, 19.7-27.0%), 7.1% (95% CI, 5.2-9.7%) and 1.7% (95% CI, 0.9-3.3%); respectively. All L. monocytogenes, all E. coli O157:H7 and 93.0% of S. enterica isolates resisted at least one antimicrobial clas...
Source: Comparative Immunology, Microbiology and Infectious Diseases - Category: Infectious Diseases Source Type: research
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