Influence of lung transplantation on the essential fatty acid profile in cystic fibrosis

Cystic fibrosis (CF) is a recessive genetic disease resulting from mutations in the CF transmembrane conductance regulator (CFTR) gene. Despite marked improvements in CF treatment, pulmonary disease remains the main cause of morbidity and mortality.
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - Category: Biomedical Science Authors: Source Type: research

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Pneumocystis pneumonia (PCP) remains the most frequent AIDS-defining illness in developed countries. This infection also occurs in non-AIDS immunosuppressed patients, e.g., those who have undergone an organ transplantation. Moreover, mild Pneumocystis jirovecii infections related to low pulmonary fungal burden, frequently designated as pulmonary colonization, occurs in patients with chronic pulmonary diseases, e.g., cystic fibrosis (CF). Indeed, this autosomal recessive disorder alters mucociliary clearance leading to bacterial and fungal colonization of the airways. This mini-review compiles and discusses available inform...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Respiratory infection with nontuberculous mycobacteria (NTM) has become a growing concern in children and young people with cystic fibrosis (CF) [1]. Mycobacterium abscessus, in particular, has been associated with an increased decline in lung function and is a contraindication to lung transplantation in many centers [2,3]. Treatment regimens for M. abscessus are complex, prolonged and associated with significant adverse effects. Epidemiological studies of NTM in children with CF are limited and risk factors for infection are poorly understood.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Short Communication Source Type: research
A man in his mid-20s with cystic fibrosis developed acute vision loss of the left eye following lung transplant. Over a week, visual acuity decreased to no light perception in both eyes. What would you do next?
Source: JAMA Ophthalmology - Category: Opthalmology Source Type: research
Data regarding the prevalence of metallo- β-lactamases (MBLs) among Pseudomonas aeruginosa isolates in cystic fibrosis patients are scarce. Furthermore, there is limited knowledge on the effect of MBL production o...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Case report Source Type: research
Cystic fibrosis (CF) is a chronic, genetic, incurable disease that affects primarily the respiratory and gastrointestinal systems. End-stage lung disease is the leading cause of death in people with CF, and lu...
Source: BMC Pulmonary Medicine - Category: Respiratory Medicine Authors: Tags: Case report Source Type: research
Exercise is increasingly recognised as an important component of disease management in cystic fibrosis (CF) [1]. Aerobic capacity, in particular the amount of oxygen uptake during maximal exercise (VO2peak), is highly predictive of long-term morbidity and mortality [2 –4]. VO2peak and other metrics calculated from lab-based cardio-pulmonary exercise testing (CPET) such as the ventilatory equivalents for O2 and CO2 (Ve/VO2 and Ve/VCO2 respectively), are strong predictors of hospitalisation [5], death and lung transplantation [4].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Source Type: research
Cystic Fibrosis (CF) is the most common life shortening genetic disorder with a worldwide prevalence of about 1 in 4000 births. CF is a multi-organ disease, affecting lungs and digestive system. The daily intensive treatment has multiple components and is considered a heavy burden on patients and their families. Although life expectancy has increased over the past decade and is expected to improve further with promising CFTR modulators, no cure is presently available. Thus far, lung transplantation (LTX) is the only option to overcome respiratory insufficiency, but LTX involves further chronic comorbidities requiring intensive treatment.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Source Type: research
Purpose of review The review of infections in lung transplantation is beyond the scope of this article as it is a comprehensive topic, however we aim to focus on infections with multidrug-resistant (MDR) microorganisms in this patient population. Recent findings New emerging clinical studies have provided data regarding outcomes in lung transplant recipients with MDR bacterial infections. Summary Isolation of MDR bacteria from lung donors preoperatively has not been associated with worse outcomes in recipients. Patients with cystic fibrosis colonized with MDR bacteria do not have increased 1 year mortality rates co...
Source: Current Opinion in Organ Transplantation - Category: Surgery Tags: INFECTIOUS DISEASES: Edited by Emily Blodget Source Type: research
Objectives: To compare intraoperative patterns among patients based on their primary pulmonary disease (cystic fibrosis [CF], chronic obstructive pulmonary disease [COPD]/emphysema [CE], and pulmonary fibrosis [PF]) during double- lung transplantation. The following 3 major outcomes were reported: blood transfusion, extracorporeal membrane oxygenation (ECMO) management, and the possibility of immediate extubation at the end of surgery.Design: Retrospective analysis of a prospectively maintained database, including donor and recipient characteristics and intraoperative variables.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Original Article Source Type: research
CONCLUSION: Pre-transplant employment is the dominant factor influencing lung transplantation employment in people with cystic fibrosis. People with cystic fibrosis undergoing lung transplantation should be encouraged to work for as long as their health status permits. Professional reintegration after successful lung transplantation should be supported by a multi-disciplinary lung transplant team. PMID: 32667678 [PubMed - as supplied by publisher]
Source: Swiss Medical Weekly - Category: General Medicine Authors: Tags: Swiss Med Wkly Source Type: research
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