Iron-Induced Derangement in hepatic Δ-5 and Δ-6 Desaturation Capacity and Fatty Acid Profile Leading to Steatosis: Impact on Extrahepatic Tissues and Prevention by Antioxidant-Rich Extra Virgin Olive Oil
Iron, an essential micronutrient, induces pathological conditions at cellular concentrations outranging physiological levels, such as exacerbation of alcoholic liver disease [1] and development and progression of non-alcoholic fatty liver disease (NAFLD) [2] that involve iron overloading. NAFLD is a common metabolic disorder associated with type 2 diabetes, obesity and the side adverse effects of some drug therapies [2,3]. Iron-induced liver pathology is associated with its involvement in oxidation-reduction processes leading to the generation of reactive oxygen species (ROS), with the concomitant oxidative deterioration of biomolecules and loss of their functions [4].
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - Category: Biomedical Science Authors: Cynthia Barrera, Rodrigo Valenzuela, Miguel A. Rinc ón, Alejandra Espinosa, Sandra López-Arana, Daniel González-Mañan, Nalda Romero, Romina Vargas, Luis A. Videla Source Type: research
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