Na,K-ATPase as a target for endogenous cardiotonic steroids: what’s the evidence?

Publication date: Available online 22 January 2020Source: Genes &DiseasesAuthor(s): Sergei N. Orlov, Artem M. Tverskoi, Svetlana V. Sidorenko, Larisa V. Smolyaninova, Olga D. Lopina, Nickolai O. Dulin, Elizaveta A. KlimanovaAbstractWith an exception of few reports, the plasma concentration of ouabain and marinobufagenin, mostly studied cardiotonic steroids (CTS) assessed by immunoassay techniques, is less than 1 nM. During the last 3 decades, the implication of these endogenous CTS in the pathogenesis of hypertension and other volume-expanded disorders is widely disputed. The threshold for inhibition by CTS of human and rodent α1-Na,K-ATPase is ∼1 and 1000 nM, respectively, that rules out the functioning of endogenous CTS (ECTS) as natriuretic hormones and regulators of cell adhesion, cell-to-cell communication, gene transcription and translation, which are mediated by dissipation of the transmembrane gradients of monovalent cations. In several types of cells ouabain and marinobufagenin at concentrations corresponding to its plasma level activate Na,K-ATPase, decrease the [Na+]i/[K+]i-ratio and increase cell proliferation. Possible physiological significance and mechanism of non-canonical Na+i/K+i-dependent and Na+i/K+i-independent cell responses to CTS are discussed.
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research

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Publication date: March 2020Source: Journal of Vascular and Interventional Radiology, Volume 31, Issue 3, SupplementAuthor(s): R. Cobb, S. Abdulla, S. Lee, N. Liss, G. Cohen, M. Gibbons, D. Yu, X. Lu
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
(Elsevier) Prematurely born babies often need oxygen therapy to prevent brain damage or death. Unfortunately, excessive oxygen can damage immature lungs and cause severe life-long problems including bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH). A new study in The American Journal of Pathology, published by Elsevier, provides insights into the important role that the hormone adrenomedullin plays in the development, recovery, and prevention of BPD and PH.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Background: Total hip arthroplasty (THA) is an effective treatment for symptomatic osteoarthritis after failed nonsurgical therapies. Minimizing perioperative complications is critical for faster recovery and shorter hospital stay. The primary aim of this study was to identify predictors of perioperative major complications (MC) and mortality after THA, and to use these predictors to develop a risk scoring system. Methods: The 2006-2016 National Surgical Quality Improvement Program (NSQIP) database was queried for adult patients who underwent primary elective THA performed under general or neuraxial anesthesia. Univar...
Source: Current Orthopaedic Practice - Category: Orthopaedics Tags: Original Research Source Type: research
According to this study: A large-scale, multinational study shows that the four first-line drug classes used to initiate monotherapy for hypertension are generally comparable.Thiazide and thiazide-like diuretics, however, had effectiveness and safety advantages over angiotensin-converting enzyme inhibitors.
Source: AJN - Category: Nursing Tags: Journal Watch Source Type: research
This study demonstrated that the DMR assay has great potential for determining the pharmacological parameters of ligands. This work may serve as guidance for other receptor and ligand assays.
Source: Journal of Pharmacological and Toxicological Methods - Category: Drugs & Pharmacology Source Type: research
European Journal of Heart Failure, EarlyView.
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Editorial Comment Source Type: research
Authors: Loutradis C, Sarafidis P Abstract Introduction: Hypertension is the most common co-morbidity in patients with chronic kidney disease (CKD), with prevalence gradually increasing across CKD Stages to the extent that about 90% of end-stage renal disease (ESRD) patients are hypertensives. Several factors contribute to blood pressure (BP) elevation and guide the therapeutic interventions that should be employed in these patients.Areas covered: This review summarizes the existing data for the management of hypertension, regarding optimal BP targets and the use of major antihypertensive classes in patients with C...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
DISCUSSION: Hypercalcemia is a rare but possible primary presenting symptom of ovarian cancer. In these patients, serum calcium measurements could possibly serve as a tumor marker for disease. PMID: 32069206 [PubMed - in process]
Source: The Permanente journal - Category: General Medicine Tags: Perm J Source Type: research
ConclusionsWe found a significantly increased five-year survival rate for heart-kidney transplant recipients compared to isolated heart transplant recipients with renal impairment. Lack of improvement in five-year post-operative outcomes for heart-kidney recipients in the setting of higher risk pre-transplant clinical characteristics suggests decreased selectivity regarding heart-kidney recipients. Continued scrutiny and evaluation of post-operative outcomes are required to ensure just and appropriate utilization of organs.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
One of the most important things to understand about heart health is that a woman ’s needs change over time. Risk factors for heart disease like high blood pressure and high cholesterol can become more important as a woman ages.  Hypertension and high cholesterol are not things we may feel. This is why hypertension is called […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Cardiology Source Type: blogs
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