Corrigendum re “Periurethral Injection of Autologous Adipose-Derived Stem Cells with Controlled-Release Nerve Growth Factor for the Treatment of Stress Urinary Incontinence in a Rat Model” Eur Urol 2011;59:155–63

Publication date: Available online 21 January 2020Source: European UrologyAuthor(s): Weiming Zhao, Cheng Zhang, Chengjun Jin, Zijian Zhang, Deling Kong, Wanhai Xu, Youcheng Xiu
Source: European Urology - Category: Urology & Nephrology Source Type: research

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Nature Reviews Urology, Published online: 23 January 2020; doi:10.1038/s41585-019-0273-4Urethral injection of bulking agents or stem cell formulations are minimally invasive approaches to stress urinary incontinence. Hillary and colleagues summarize data on the efficacy and safety of bulking agents compared with conventional treatments, and discuss current knowledge of the use of stem cell formulations and acellular, stimulatory injection-based therapies for the treatment of this disorder.
Source: Nature Reviews Urology - Category: Urology & Nephrology Authors: Source Type: research
Anal sphincter injury leads to fecal incontinence. Based on the regenerative capability of laser and human adipose-derived stem cells (hADSCs), this study was designed to assess the effects of co-application o...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Research Source Type: research
Abstract Purinergic signaling was proposed in 1972, after it was demonstrated that adenosine 5'-triphosphate (ATP) was a transmitter in nonadrenergic, noncholinergic inhibitory nerves supplying the guinea-pig taenia coli. Later, ATP was identified as an excitatory cotransmitter in sympathetic and parasympathetic nerves, and it is now apparent that ATP acts as a cotransmitter in most, if not all, nerves in both the peripheral nervous system and central nervous system (CNS). ATP acts as a short-term signaling molecule in neurotransmission, neuromodulation, and neurosecretion. It also has potent, long-term (trophic) ...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Shilpa Sharma, Devendra K GuptaJournal of Indian Association of Pediatric Surgeons 2019 24(4):237-246 The rapidly expanding field of tissue engineering along with stem cell therapy has a promising future in pediatric urological conditions. The initial struggle seemed difficult in renal regeneration but a functional biounit has been developed. Urine excretion has been demonstrated successfully from stem cell-generated embryonic kidneys. Three-dimensional (3D) stem cell-derived organoids are the new paradigm in research. Techniques to regenerate bladder tissue have reached the clinic, and the urethra is close behind. 3D bio...
Source: Journal of Indian Association of Pediatric Surgeons - Category: Surgery Authors: Source Type: research
MULTIPLE DOSES OF STEM CELLS MAINTAIN URETHRAL FUNCTION IN A MODEL OF NEUROMUSCULAR INJURY RESULTING IN STRESS URINARY INCONTINENCE. Am J Physiol Renal Physiol. 2019 Aug 14;: Authors: Janssen K, Lin DL, Hanzlicek B, Deng K, Balog BM, van der Vaart CH, Damaser MS Abstract Stress urinary incontinence (SUI) is more prevalent among women who deliver vaginally than women who have had a caesarean section, suggesting that tissue repair after vaginal delivery is insufficient. A single dose of mesenchymal stem cells (MSCs) has been shown to partially restore urethral function in a model of SUI. The aim of this...
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research
AbstractPurpose of ReviewDiscogenic low back pain (DLBP) stems from pathology in one or more intervertebral discs identified as the root cause of the pain. It is the most common type of chronic low back pain (LBP), representing 26 –42% of attributable cases.Recent FindingsThe clinical presentation of DLBP includes increased pain when sitting, coughing, or sneezing, and experiencing relief when standing or ambulating. Dermatomal radiation of pain to the lower extremity and neurological symptoms including numbness, motor weakness, and urinary or fecal incontinence are signs of advanced disease with disc prolapse, nerve...
Source: Current Pain and Headache Reports - Category: Neurology Source Type: research
Purpose of review Perianal Crohn's disease is a morbid and disabling condition, notoriously difficult to successfully treat with conventional medical and surgical therapies. Mesenchymal stem cells (MSCs) are an emerging novel therapy for perianal Crohn's disease. Recent findings Over 300 patients with perianal Crohn's disease have now been treated with MSCs in the context of clinical trials. All trials have demonstrated safety, and efficacy superior to conventional therapy with biologics and surgical intervention. This was consistent despite the heterogeneity in study protocols including variability in cell dosing, mo...
Source: Current Opinion in Gastroenterology - Category: Gastroenterology Tags: INFLAMMATORY BOWEL DISEASE: Edited by Miguel Regueiro Source Type: research
Purpose of review Update on recent regenerative medicine approaches to the treatment of stress urinary incontinence (SUI) caused by intrinsic sphincter deficiency (ISD). Recent findings In the treatment of female SUI/ISD, results using different types of cellular therapy have been disappointing, and new approaches are desirable. To advance our regenerative medicine approaches to SUI/ISD, it is critical to utilize animal models that best parallel the pathophysiology of this disease in women. Many current animal models mimic acute SUI/ISD. However, SUI/ISD in women is usually a chronic condition resulting from previous ...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: TISSUE ENGINEERING AND STEM CELLS: Edited by Christopher R. Chapple and Sheila MacNeil Source Type: research
Purpose of review Stress urinary incontinence (SUI) is one of the most prevalent disorders of the lower urinary tract. Actual standard conservative and surgical therapeutic modalities are offering a symptomatic relief without treating the underlying disorder. Therefore, advances in cell-based regenerative medicine have implemented the use of autologous cells with the aim to treat urinary incontinence. Recent findings Different types of cells have been investigated to regain the function of the rhabdosphincter muscle in the urethral closure complex: myogenic progenitor cells, adipose tissue-derived stromal cells and me...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: TISSUE ENGINEERING AND STEM CELLS: Edited by Christopher R. Chapple and Sheila MacNeil Source Type: research
Purpose of review This review identifies the clinical complications associated with the design of the current polyproplylene mesh materials used for the treatment of stress urinary incontinence and pelvic organ prolapse. Following on from this, new alternative materials under development for pelvic floor repair are reviewed. Recent findings It is well accepted that the textile properties of the current polypropylene surgical meshes are not suitable for the pelvic floor environment. This together with the chemical nature of the current mesh leads to complications whenever implanted in the pelvic floor of women. New alt...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: TISSUE ENGINEERING AND STEM CELLS: Edited by Christopher R. Chapple and Sheila MacNeil Source Type: research
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